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All 3 posts Subject: modified version of meth grignard Please login to post Down

ning
(acetaminophanatic)
05-04-04 03:16
No 504690
User Picture       modified version of meth grignard

It seems the big problem with the acetaldehyde methylimine grignard reaction is the instability and annoyance of preparing the methylimine. It polymerizes easily, and must be dried rigorously for the grignard to yeild well. How annoying!

What ning proposes is a variation of a well-worn procedure to make PCP--the Bruylants reaction.

I.E. Post 179639 (Bwiti: "Help! - 1-Methylaminocyclohexanecarbonitrile", Methods Discourse)

Bwiti made (and unfortunately couldn't use) methylaminocyclohexylcarbonitrile. Now let me ask you this:

What would happen if acetaldehyde, methylamine HCl, and NaCN were reacted? I bet you dollars to donuts the result would bee a fair yield of methylaminoethylcarbonitrile, which could bee based, extracted into nonpolar solvent, dried, and reacted with benzylmagnesium grignard at one's sweet leisure with none of the trouble of the acetaldehyde methylimine route.

Yes, cyanide is poisonous. PCP bees handle it all the time. It can also be made OTC. Ning thinks if this works it might not be such a bad trade, for the convenience and higher yield of a bruylants reaction.

A reaction like this could get PCP bees in the meth market! laugh

Actually, the reason ning likes the grignard method is because it makes SAR exploration so easy! It's like frickin lego blocks here! Any amine + any aldehyde/ketone + any substituted benzyl chloride --> substituted phenethylamine.
With the ease of chloromethylation to produce benzyl chlorides in one step from benzenes, this makes a TERRIFYING number of amphetamine derivatives in reach.

Someone should apply this reaction to MDMA.

catechol --> methylenedioxybenzene --> methylenedioxybenzyl chloride --> MDMA

I've been chased by both cops and robbers. So what does that make me?

josef_k
(Hive Bee)
05-04-04 14:29
No 504777
      Are you sure the grignard reacts in the way...

Are you sure the grignard reacts in the way you want? Perhaps it just reacts with the nitrile group to make a ketone?

Rhodium
(Chief Bee)
05-04-04 16:06
No 504798
User Picture       very limited scope

For one thing, it could only work with dialkylamines, forming a tertiary amine intermediate - else the aminonitrile would have an acidic N-H function left, which would quench the grignard reagent.

^{The Hive - Clandestine Chemists Without Borders}

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	All 3 posts		Subject: modified version of meth grignard		Please login to post		Down


		ning (acetaminophanatic) 05-04-04 03:16 No 504690				modified version of meth grignard
						It seems the big problem with the acetaldehyde methylimine grignard reaction is the instability and annoyance of preparing the methylimine. It polymerizes easily, and must be dried rigorously for the grignard to yeild well. How annoying! What ning proposes is a variation of a well-worn procedure to make PCP--the Bruylants reaction. I.E. Post 179639 (Bwiti: "Help! - 1-Methylaminocyclohexanecarbonitrile", Methods Discourse) Bwiti made (and unfortunately couldn't use) methylaminocyclohexylcarbonitrile. Now let me ask you this: What would happen if acetaldehyde, methylamine HCl, and NaCN were reacted? I bet you dollars to donuts the result would bee a fair yield of methylaminoethylcarbonitrile, which could bee based, extracted into nonpolar solvent, dried, and reacted with benzylmagnesium grignard at one's sweet leisure with none of the trouble of the acetaldehyde methylimine route. Yes, cyanide is poisonous. PCP bees handle it all the time. It can also be made OTC. Ning thinks if this works it might not be such a bad trade, for the convenience and higher yield of a bruylants reaction. A reaction like this could get PCP bees in the meth market! Actually, the reason ning likes the grignard method is because it makes SAR exploration so easy! It's like frickin lego blocks here! Any amine + any aldehyde/ketone + any substituted benzyl chloride --> substituted phenethylamine. With the ease of chloromethylation to produce benzyl chlorides in one step from benzenes, this makes a TERRIFYING number of amphetamine derivatives in reach. Someone should apply this reaction to MDMA. catechol --> methylenedioxybenzene --> methylenedioxybenzyl chloride --> MDMA I've been chased by both cops and robbers. So what does that make me?



		josef_k (Hive Bee) 05-04-04 14:29 No 504777				Are you sure the grignard reacts in the way...
						Are you sure the grignard reacts in the way you want? Perhaps it just reacts with the nitrile group to make a ketone?



		Rhodium (Chief Bee) 05-04-04 16:06 No 504798				very limited scope
						For one thing, it could only work with dialkylamines, forming a tertiary amine intermediate - else the aminonitrile would have an acidic N-H function left, which would quench the grignard reagent. ^{The Hive - Clandestine Chemists Without Borders}

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