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All 2 posts Subject: methphenidate synth Please login to post Down

elosejohn
06-29-04 08:30
      methphenidate synth
(Rated as: UTFSE!)

Rhodium
(Chief Bee)
06-29-04 14:59
No 516296
User Picture       threo-Methylphenidate Hydrochloride

The spelling "methylphenidate" may aid you in your searches.

Also see the following article:

Approaches to the Preparation of Enantiomerically Pure (2R,2'R)-(+)-threo-Methylphenidate Hydrochloride
Mahavir Prashad
Adv. Synth. Catal. 343(5), 379-392 (2001) (https://www.rhodium.ws/pdf/threo-methylphenidate.pdf)

Abstract
Various approaches to the preparation of enantiomerically pure (2R,2'R)-(+)-threo-methylphenidate hydrochloride (1) are reviewed. These approaches include synthesis using enantiomerically pure precursors obtained by resolution, classical and enzyme-based resolution approaches, enantioselective synthesis approaches, and approaches based on enantioselective synthesis of (2S,2'R)-erythro-methylphenidate followed by epimerization at the 2-position.

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	All 2 posts		Subject: methphenidate synth		Please login to post		Down


		elosejohn 06-29-04 08:30				methphenidate synth (Rated as: UTFSE!)



		Rhodium (Chief Bee) 06-29-04 14:59 No 516296				threo-Methylphenidate Hydrochloride
						The spelling "methylphenidate" may aid you in your searches. Also see the following article: Approaches to the Preparation of Enantiomerically Pure (2R,2'R)-(+)-threo-Methylphenidate Hydrochloride Mahavir Prashad Adv. Synth. Catal. 343(5), 379-392 (2001) (https://www.rhodium.ws/pdf/threo-methylphenidate.pdf) Abstract Various approaches to the preparation of enantiomerically pure (2R,2'R)-(+)-threo-methylphenidate hydrochloride (1) are reviewed. These approaches include synthesis using enantiomerically pure precursors obtained by resolution, classical and enzyme-based resolution approaches, enantioselective synthesis approaches, and approaches based on enantioselective synthesis of (2S,2'R)-erythro-methylphenidate followed by epimerization at the 2-position. ^{The Hive - Clandestine Chemists Without Borders}

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