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	Novel Discourse

	All 2 posts		Subject: reductive amination with mol. sieves and Zn/iPrOH		Please login to post		Down

		indole_amine (Stranger) 09-18-04 00:43 No 531876				reductive amination with mol. sieves and Zn/iPrOH
						seems like a nice one-pot method for the reduction of imines with Zn/AcOH... Synthesis of Bis[di(2-pyridyl)methyl]amine (BDPMA) by a Novel One-Pot Multi-Step Reductive Amination with Molecular Sieves and Zn/iPrOH (Michael Renz, Catherine Hemmert, Bernard Meunier) European Journal of Organic Chemistry 1998, 7 (1271-1273) Keywords Reductive amination; Zinc; Pentadentate ligand; Polypyridine ligand Abstract Bis[di(2-pyridyl)methyl]amine (BDPMA) has been syn-thesized by refluxing di-2-pyridyl ketone and di-(2-pyridyl)methylamine in isopropanol in the presence of molecular sieves and acetic acid and subsequent reduction with zinc dust. The established methods for reductive amination, i.e. NaBH3CN, NaBH(OAc)3 and NaBH4, failed in the synthesis of BDPMA due to a disfavored equilibrium towards the imine formation and therefore long reaction times were required, involving side reactions. The presented method can be used on large-scales and tolerates aromatic heterocycles as functional groups. indole_amine
		Lego (Hive Bee) 09-18-04 10:06 No 531965				Please post in the existing thread
						Post 413690 (Lego: "Red. amination with Zn/iPrOH and mol. sieves", Novel Discourse) The tendency is to push it as far as you can

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Date: 11-23-24, Release: 1.6 (10-04-15), Links: static, unique