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All 21 posts Subject: Analgesic refs, a compendium Please login to post Down

Cyrax
(Hive Bee)
09-29-02 22:42
No 362086
      Analgesic refs, a compendium
(Rated as: excellent)

Snoopy went to the library, did some research for his master and came up with a list of refs. for the synthesis of several analgesics.

Anileridine

* J. Am. Chem. Soc. 78, 2342 (1956)
* U.S. Pat. 2,966,490
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2966490&ID=US+++2966490A1+I+

Bezitramide

* Belg. Pat. 633,495
* U.S. Pat. 3,196,157
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US3196157&ID=US+++3196157A1+I+

Clonitazene

* Experientia 13, 400 (1957)
* U.S. Pat. 2,935,514
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2935514&ID=US+++2935514A1+I+

Desomorphine

* J. Amer. Chem. Soc. 55, 3863 (1933)

Dextromoramide

* J. Amer. Chem. Soc. 78, 3862 (1956)
* Brit. Pat. 822,055
http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=GB822055&ID=GB++++822055A++I+

Diampromide

* J. Amer. Chem. Soc. 81, 1518 (1959)
* U.S. Pat. 2,944,081
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2944081&ID=US+++2944081A1+I+

Diethylthiambutene

* J. Chem. Soc. (pg)885 (1950)
* U.S. Pat. 2,561,899
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2561899&ID=US+++2561899A1+I+

Dimenoxadol

* Arch. Pharm. 288, 42 (1955)
* Pharm. Chem. J. 8, 189 (1974) (improved method)

Dimepheptanol

* J. Amer. Chem. Soc. 71, 57 (1949)
* J. Org. Chem. 17, 321 (1952)
* U.S. Pat. 2,565,592
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2565592&ID=US+++2565592A1+I+
* U.S. Pat. 2,668,814
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2668814&ID=US+++2668814A1+I+
* U.S. Pat. 2,649,445
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2649445&ID=US+++2649445A1+I+

Dioxaphetyl Butyrate

* J. Amer. Chem. Soc. 71, 57 (1949)
* J. Chem. Soc. (pg)500, (1949)
* U.S. Pat. 2,230,774
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2230774&ID=US+++2230774A1+I+

Diphenoxylate

* U.S. Pat. 2,898,340
http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2898340&ID=US+++2898340A1+I+

Dipipanone

* J. Chem. Soc. (pg)2158, (1950)
* Brit. Pat. 654,975
http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=GB654975&ID=GB++++654975A++I+

Snoopy is a good dog.

Bwiti
(PVC-Analog Taste-Tester)
09-30-02 02:15
No 362166
User Picture       Dipipanone Med. J. 12, 304-307 (1960) (variations ...

Dipipanone
Med. J. 12, 304-307 (1960) (variations using phenyllithium)

1-Methyl-4-Piperidinols Having Also A Hydrocarbon Substituent In The 4-Position
US2765315
US2498433

Love my country, fear my government.

Cyrax
(Hive Bee)
10-09-02 11:38
No 366439
      Here's the link to the bezitramide Belgium ...

Here's the link to the bezitramide Belgium patent. Those dudes from Janssen Pharmaceutics are really great.

http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=BE633495&ID=BE++++633495A++I+

GC_MS
(Hive Bee)
10-09-02 11:48
No 366444
User Picture       fentanyl

A friend told me they developed fentanyl. Can't confirm that, but I do know they like to play around with fentanyl analogues.

http://www.janssenpharmaceutica.be/index_E.asp

Durogesic... nice smile .
WOMAN.ZIP: Great Shareware, but be careful of viruses...

Cyrax
(Hive Bee)
10-09-02 12:22
No 366456
      Your friend is right, they invented fentanyl.

Your friend is right, they invented fentanyl. They developped dextromoramide too.

http://www.janssenpharmaceutica.be/health_research3_E.asp

SPISSHAK
(Hive Bee)
10-11-02 01:37
No 367102
      A question about a patent

BTW those are good finds.
The question here is about the patents that BWITi included.
In one of the methods orthophosphoric acid is employed to facilitate esterification or cyclization.
If one were using this method with more readilly available alphamethylstyrene, would there be a danger of MPTP formation.
It seems possible.
Another question if so would using the method employing only propionic acid, 1,3,5 hexahydro trimethyl triazine, and the olefin be advised instead.
And lastly does anyone understand the fundemental mechanism in this cyclization and esterification reaction going on in the above processes, or know where I can get information on that reaction mechanism.
It looks very tantilizing, although possibly dangerous.

Cyrax
(Hive Bee)
10-11-02 11:22
No 367277
      prodine

US patent 2,765,315 seems to be the only safe way to make prodine, since a file on Rhodium's site says that it is unlikely that MPTP is formed as a side product.

https://www.rhodium.ws/pdf/prodine.pdf

SPISSHAK
(Hive Bee)
10-11-02 13:12
No 367291
      Well cyrax

Then those are the same methods I was speaking of and on the plus side very convenient processes.
but in the stricter sense I think they were actually saying that the dehydration product which in that case is 1,3-dimethyl-4-phenyltetrahydropiperidine does not have the nuerotoxic properties of it's cousin.
I could be wrong so I'll double check that.
Nope, you were right.
But parkinson's disease at age 30 is not a goal of mine so it is important to know for sure.
In the real world I live in alpha-ethylstyrene isn't commercially available so the methyl homlouge would be used, as it is more common in industry.
I see that they use the anhydride to bind water, this sounds important because, if water were present the ester could hydrolyse, and the resultant alcohol may be prone to dehydration.

Cyrax
(Hive Bee)
10-11-02 13:34
No 367295
      Yes, you're right ... I was a little bit ...

Yes, you're right ... I was a little bit confused. The dehydratation product in the prodine synthesis would of course be 1,3-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine. Mabey this compound isn't neurotoxic. I don't know. But if you use alpha-methyl styrene and it dehydratates, you would get MPTP.
If I were you, I 'd stick to the described prodine synthesis. Alpha-ethyl styrene can be prepared by a Wittig reaction between a methyl halide and propiophenone.

SPISSHAK
(Hive Bee)
10-11-02 13:43
No 367296
      Very good

That's just the little research tool I needed don't you just love named reactions.
Makes searching for the info a lot easier.
Thanks for that tip.
I don't know about you but a syringe full of smack has become one of my favorate past times as of lately, due to injuries and what not analgesics are a great companion.
One question it appears triphenylphosphine is crucial to this reaction, or in the wittig horner variation, triethylphosphite, these don't sound very otc, hit another brick wall.
But there may be a way around this?
Would it be possible to prepare this from ethanol and PCL3?
Or would a straight up exchange occur and give phosphorus acid and chloroethane?
Hmmm...

Cyrax
(Hive Bee)
10-11-02 15:53
No 367333
      Triphenylphosphine is a very common lab reagent.

Triphenylphosphine is a very common lab reagent. I think PCl₃ would be more suspicious to acquire, since that compound can be used for the synthesis of organophosphorus compounds (read: nerve gasses). It would certainly be overkill to try make it yourself (I mean the triphenylphosphine, not the sarin smile ).
Check out the post of Rhodium and the other posts of this thread: Post 363416 (Rhodium: "Wittig gets my vote", Chemistry Discourse).
If you really want to do something exotic, you can use the Tebbe reagens.

SPISSHAK
(Hive Bee)
10-11-02 17:18
No 367355
      Thanks those Pdf's are

A goldmine and yes that tebbe reagent looks pretty exotic.
The horner variation using triethyl phosphite is easier to do.
It gives a diethylphosphonate ethyl ester on reaction with alkyl chloride.
This reacts with ketones in the presence of bases to afford alkenes and a diethyl phosphonic acid.

Rhodium
(Chief Bee)
05-08-03 23:54
No 432214
User Picture       Wittig Synthesis of alpha-Ethylstyrene
(Rated as: excellent)

Wittig Synthesis of alpha-Ethylstyrene

-Ethylstyrene (2-phenyl-1-butene) was prepared by the Wittig reaction from ethyl phenyl ketone (propiophenone) and methyltriphenylphosphorane according to the following general procedure:

To a solution of diisopropylamine (7.7 g, 76 mmol) in 100 mL of anhydrous tetrahydrofuran cooled at -30°C was added n-butyllithium (51 mL, 1.5 M in hexane, 76 mmol) dropwise under nitrogen. After 15 min, methyltriphenylphosphonium iodide (30.7 g, 76 mmol) was added under stirring.
The cold bath was removed, and the mixture was allowed to react 2 h at room temperature. The ketone (76 mmol) was added dropwise, and the mixture was allowed to react for a period of time ranging from 1 to 10 h depending on the structure of the ketone (follow the reaction on TLC).
After filtration and solvent evaporation, light petroleum was added and most of the crystallized triphenylphosphine oxide was removed by filtration. Chromatography of the resulting solution on silica gel (light petroleum as the eluent) and successive distillation gave -ethylstyrene more than 99.9% pure by GLC analysis.

-Ethylstyrene (2-phenyl-1-butene): 68%; bp₁₅ 64-64.5°C;

¹H NMR 7.50-7.15 (m, 5 H), 5.28 (m, 1 H), 5.07 (m, 1 H), 2.52 (b q, J = 7.7 Hz, 2 H), 1.10 (t, J = 7.7 Hz, 3 H);
MS m/z 132 (M⁺, 67), 117 (100), 103 (9), 91 (33), 77 (16).

Reference:

J. Org. Chem., Vol. 56(15), 4772-4778 (1991) (https://www.rhodium.ws/pdf/alpha-ethylstyrene-0.pdf)

SPISSHAK
(Hive Addict)
05-09-03 17:35
No 432345
      That's good

but the horner adaptation would be easier because you have choices of different more commonly available bases, the reaction is more forgiving, and the by-products are water soluble so you can avoid having to use chromatography to isolate the end product instead you can get the product by solvent extraction.
I looked into the availability of propiophenone and it's only documented use is a pharmacuetical intermediate, this makes aqusition of this stuff very hard, do you have any suggestions?

Rhodium
(Chief Bee)
05-09-03 18:19
No 432352
User Picture       Propiophenone

Propiophenone is a common chemical in organic synthesis, it's available everywhere except OTC.

Pimpo
(Stranger)
05-15-03 16:46
No 433363
      k-selective opiods

They don't seem to be much fun, but anyway... crazy

"Struktur – Wirkungsbeziehungen an Bicyclo[3.3.1]nonan-9-on-1,5-diestern und anderen k-selektiven Opioiden"

http://webdoc.gwdg.de/ebook/w/2002/pub/bio/99H202/prom.pdf, very extensive, several megs, German

Lilienthal
(Moderator)
05-15-03 19:30
No 433387
User Picture       Not much fun? Post 433158

Not much fun? Post 433158 (ChemisTris: "Salvinorin A (journal article)", General Discourse)

Pimpo
(Stranger)
05-16-03 20:18
No 433601
      Thanks for telling me...

I didn't know about that! blush I wonder why the German paper states k-agonists to be of limited therapeutic use, because they cause sedation, dysphoria and diuresis (page 8). No mention of hallucinations or psychosis or something. Kind of confusing.

Bwiti
(PVC-Analog Taste-Tester)
05-18-03 04:33
No 433833
User Picture       a-Ethylstyrene..

If you're bent on producing a prodine-like compound, then I advise you to take a close look at that Wittig synthesis of alpha-ethylstyrene that Rhodium posted, because it's hard to find someone that'll track down and sell a-ethylstyrene. Maybe other prodine-analogue precursors are easier to get, but I can only speak of the above precursor.. Which precursor would be the easiest to obtain? Availability of prodine-analogue precursors? Peace! cool

Love my country, fear my government.

Megatherium
(Hive Bee)
10-22-03 22:26
No 466183
      Analgesics
(Rated as: good read)

Buprenorphine

Patent US3433791
Patent DE1620206

Pentazocine

Patent BE611000
JMC (1964) vol 7 p 123

Pethidine

Patent US2167351
Patent DE679281

Methadone

Patent DE865314
Patent DE870700
Patent DE890506
Justus Liebigs Ann. Chem. (1948) vol 561 p 52 - Post 483448 (Rhodium: "Bockmühl's Original Methadone Synthesis", Methods Discourse)

racemate resolution:
Patent US2644010
Patent US2983757

The Narcs

Megatherium
(Hive Bee)
10-23-03 22:38
No 466410
      More analgesics
(Rated as: good read)

dextromethorphan

Patent US2676177
Helv Acta (1951) vol 34 p 2211

dextromoramide

Patent BE544757
Patent DE1117126

nor-methadone

Patent DE865314
Patent DE870700
Justus Liebigs Ann Chem (1948) vol 561 p 52 - Post 483448 (Rhodium: "Bockmühl's Original Methadone Synthesis", Methods Discourse)

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	All 21 posts		Subject: Analgesic refs, a compendium		Please login to post		Down


		Cyrax (Hive Bee) 09-29-02 22:42 No 362086				Analgesic refs, a compendium (Rated as: excellent)
						Snoopy went to the library, did some research for his master and came up with a list of refs. for the synthesis of several analgesics. Anileridine * J. Am. Chem. Soc. 78, 2342 (1956) * U.S. Pat. 2,966,490 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2966490&ID=US+++2966490A1+I+ Bezitramide * Belg. Pat. 633,495 * U.S. Pat. 3,196,157 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US3196157&ID=US+++3196157A1+I+ Clonitazene * Experientia 13, 400 (1957) * U.S. Pat. 2,935,514 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2935514&ID=US+++2935514A1+I+ Desomorphine * J. Amer. Chem. Soc. 55, 3863 (1933) Dextromoramide * J. Amer. Chem. Soc. 78, 3862 (1956) * Brit. Pat. 822,055 http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=GB822055&ID=GB++++822055A++I+ Diampromide * J. Amer. Chem. Soc. 81, 1518 (1959) * U.S. Pat. 2,944,081 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2944081&ID=US+++2944081A1+I+ Diethylthiambutene * J. Chem. Soc. (pg)885 (1950) * U.S. Pat. 2,561,899 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2561899&ID=US+++2561899A1+I+ Dimenoxadol * Arch. Pharm. 288, 42 (1955) * Pharm. Chem. J. 8, 189 (1974) (improved method) Dimepheptanol * J. Amer. Chem. Soc. 71, 57 (1949) * J. Org. Chem. 17, 321 (1952) * U.S. Pat. 2,565,592 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2565592&ID=US+++2565592A1+I+ * U.S. Pat. 2,668,814 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2668814&ID=US+++2668814A1+I+ * U.S. Pat. 2,649,445 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2649445&ID=US+++2649445A1+I+ Dioxaphetyl Butyrate * J. Amer. Chem. Soc. 71, 57 (1949) * J. Chem. Soc. (pg)500, (1949) * U.S. Pat. 2,230,774 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2230774&ID=US+++2230774A1+I+ Diphenoxylate * U.S. Pat. 2,898,340 http://l2.espacenet.com/dips/bnsviewer?CY=gb&LG=en&DB=EPD&PN=US2898340&ID=US+++2898340A1+I+ Dipipanone * J. Chem. Soc. (pg)2158, (1950) * Brit. Pat. 654,975 http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=GB654975&ID=GB++++654975A++I+ Snoopy is a good dog.



		Bwiti (PVC-Analog Taste-Tester) 09-30-02 02:15 No 362166				Dipipanone Med. J. 12, 304-307 (1960) (variations ...
						Dipipanone Med. J. 12, 304-307 (1960) (variations using phenyllithium) 1-Methyl-4-Piperidinols Having Also A Hydrocarbon Substituent In The 4-Position US2765315 US2498433 Love my country, fear my government.



		Cyrax (Hive Bee) 10-09-02 11:38 No 366439				Here's the link to the bezitramide Belgium ...
						Here's the link to the bezitramide Belgium patent. Those dudes from Janssen Pharmaceutics are really great. http://l2.espacenet.com/espacenet/bnsviewer?CY=gb&LG=en&DB=EPD&PN=BE633495&ID=BE++++633495A++I+



		GC_MS (Hive Bee) 10-09-02 11:48 No 366444				fentanyl
						A friend told me they developed fentanyl. Can't confirm that, but I do know they like to play around with fentanyl analogues. http://www.janssenpharmaceutica.be/index_E.asp Durogesic... nice . WOMAN.ZIP: Great Shareware, but be careful of viruses...



		Cyrax (Hive Bee) 10-09-02 12:22 No 366456				Your friend is right, they invented fentanyl.
						Your friend is right, they invented fentanyl. They developped dextromoramide too. http://www.janssenpharmaceutica.be/health_research3_E.asp



		SPISSHAK (Hive Bee) 10-11-02 01:37 No 367102				A question about a patent
						BTW those are good finds. The question here is about the patents that BWITi included. In one of the methods orthophosphoric acid is employed to facilitate esterification or cyclization. If one were using this method with more readilly available alphamethylstyrene, would there be a danger of MPTP formation. It seems possible. Another question if so would using the method employing only propionic acid, 1,3,5 hexahydro trimethyl triazine, and the olefin be advised instead. And lastly does anyone understand the fundemental mechanism in this cyclization and esterification reaction going on in the above processes, or know where I can get information on that reaction mechanism. It looks very tantilizing, although possibly dangerous.



		Cyrax (Hive Bee) 10-11-02 11:22 No 367277				prodine
						US patent 2,765,315 seems to be the only safe way to make prodine, since a file on Rhodium's site says that it is unlikely that MPTP is formed as a side product. https://www.rhodium.ws/pdf/prodine.pdf



		SPISSHAK (Hive Bee) 10-11-02 13:12 No 367291				Well cyrax
						Then those are the same methods I was speaking of and on the plus side very convenient processes. but in the stricter sense I think they were actually saying that the dehydration product which in that case is 1,3-dimethyl-4-phenyltetrahydropiperidine does not have the nuerotoxic properties of it's cousin. I could be wrong so I'll double check that. Nope, you were right. But parkinson's disease at age 30 is not a goal of mine so it is important to know for sure. In the real world I live in alpha-ethylstyrene isn't commercially available so the methyl homlouge would be used, as it is more common in industry. I see that they use the anhydride to bind water, this sounds important because, if water were present the ester could hydrolyse, and the resultant alcohol may be prone to dehydration.



		Cyrax (Hive Bee) 10-11-02 13:34 No 367295				Yes, you're right ... I was a little bit ...
						Yes, you're right ... I was a little bit confused. The dehydratation product in the prodine synthesis would of course be 1,3-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine. Mabey this compound isn't neurotoxic. I don't know. But if you use alpha-methyl styrene and it dehydratates, you would get MPTP. If I were you, I 'd stick to the described prodine synthesis. Alpha-ethyl styrene can be prepared by a Wittig reaction between a methyl halide and propiophenone.



		SPISSHAK (Hive Bee) 10-11-02 13:43 No 367296				Very good
						That's just the little research tool I needed don't you just love named reactions. Makes searching for the info a lot easier. Thanks for that tip. I don't know about you but a syringe full of smack has become one of my favorate past times as of lately, due to injuries and what not analgesics are a great companion. One question it appears triphenylphosphine is crucial to this reaction, or in the wittig horner variation, triethylphosphite, these don't sound very otc, hit another brick wall. But there may be a way around this? Would it be possible to prepare this from ethanol and PCL3? Or would a straight up exchange occur and give phosphorus acid and chloroethane? Hmmm...



		Cyrax (Hive Bee) 10-11-02 15:53 No 367333				Triphenylphosphine is a very common lab reagent.
						Triphenylphosphine is a very common lab reagent. I think PCl₃ would be more suspicious to acquire, since that compound can be used for the synthesis of organophosphorus compounds (read: nerve gasses). It would certainly be overkill to try make it yourself (I mean the triphenylphosphine, not the sarin ). Check out the post of Rhodium and the other posts of this thread: Post 363416 (Rhodium: "Wittig gets my vote", Chemistry Discourse). If you really want to do something exotic, you can use the Tebbe reagens.



		SPISSHAK (Hive Bee) 10-11-02 17:18 No 367355				Thanks those Pdf's are
						A goldmine and yes that tebbe reagent looks pretty exotic. The horner variation using triethyl phosphite is easier to do. It gives a diethylphosphonate ethyl ester on reaction with alkyl chloride. This reacts with ketones in the presence of bases to afford alkenes and a diethyl phosphonic acid.



		Rhodium (Chief Bee) 05-08-03 23:54 No 432214				Wittig Synthesis of alpha-Ethylstyrene (Rated as: excellent)
						Wittig Synthesis of alpha-Ethylstyrene -Ethylstyrene (2-phenyl-1-butene) was prepared by the Wittig reaction from ethyl phenyl ketone (propiophenone) and methyltriphenylphosphorane according to the following general procedure: To a solution of diisopropylamine (7.7 g, 76 mmol) in 100 mL of anhydrous tetrahydrofuran cooled at -30°C was added n-butyllithium (51 mL, 1.5 M in hexane, 76 mmol) dropwise under nitrogen. After 15 min, methyltriphenylphosphonium iodide (30.7 g, 76 mmol) was added under stirring. The cold bath was removed, and the mixture was allowed to react 2 h at room temperature. The ketone (76 mmol) was added dropwise, and the mixture was allowed to react for a period of time ranging from 1 to 10 h depending on the structure of the ketone (follow the reaction on TLC). After filtration and solvent evaporation, light petroleum was added and most of the crystallized triphenylphosphine oxide was removed by filtration. Chromatography of the resulting solution on silica gel (light petroleum as the eluent) and successive distillation gave -ethylstyrene more than 99.9% pure by GLC analysis. -Ethylstyrene (2-phenyl-1-butene): 68%; bp₁₅ 64-64.5°C; ¹H NMR 7.50-7.15 (m, 5 H), 5.28 (m, 1 H), 5.07 (m, 1 H), 2.52 (b q, J = 7.7 Hz, 2 H), 1.10 (t, J = 7.7 Hz, 3 H); MS m/z 132 (M⁺, 67), 117 (100), 103 (9), 91 (33), 77 (16). Reference: J. Org. Chem., Vol. 56(15), 4772-4778 (1991) (https://www.rhodium.ws/pdf/alpha-ethylstyrene-0.pdf)



		SPISSHAK (Hive Addict) 05-09-03 17:35 No 432345				That's good
						but the horner adaptation would be easier because you have choices of different more commonly available bases, the reaction is more forgiving, and the by-products are water soluble so you can avoid having to use chromatography to isolate the end product instead you can get the product by solvent extraction. I looked into the availability of propiophenone and it's only documented use is a pharmacuetical intermediate, this makes aqusition of this stuff very hard, do you have any suggestions?



		Rhodium (Chief Bee) 05-09-03 18:19 No 432352				Propiophenone
						Propiophenone is a common chemical in organic synthesis, it's available everywhere except OTC.



		Pimpo (Stranger) 05-15-03 16:46 No 433363				k-selective opiods
						They don't seem to be much fun, but anyway... "Struktur – Wirkungsbeziehungen an Bicyclo[3.3.1]nonan-9-on-1,5-diestern und anderen k-selektiven Opioiden" http://webdoc.gwdg.de/ebook/w/2002/pub/bio/99H202/prom.pdf, very extensive, several megs, German



		Lilienthal (Moderator) 05-15-03 19:30 No 433387				Not much fun? Post 433158
						Not much fun? Post 433158 (ChemisTris: "Salvinorin A (journal article)", General Discourse)



		Pimpo (Stranger) 05-16-03 20:18 No 433601				Thanks for telling me...
						I didn't know about that! I wonder why the German paper states k-agonists to be of limited therapeutic use, because they cause sedation, dysphoria and diuresis (page 8). No mention of hallucinations or psychosis or something. Kind of confusing.



		Bwiti (PVC-Analog Taste-Tester) 05-18-03 04:33 No 433833				a-Ethylstyrene..
						If you're bent on producing a prodine-like compound, then I advise you to take a close look at that Wittig synthesis of alpha-ethylstyrene that Rhodium posted, because it's hard to find someone that'll track down and sell a-ethylstyrene. Maybe other prodine-analogue precursors are easier to get, but I can only speak of the above precursor.. Which precursor would be the easiest to obtain? Availability of prodine-analogue precursors? Peace! Love my country, fear my government.



		Megatherium (Hive Bee) 10-22-03 22:26 No 466183				Analgesics (Rated as: good read)
						Buprenorphine Patent US3433791 Patent DE1620206 Pentazocine Patent BE611000 JMC (1964) vol 7 p 123 Pethidine Patent US2167351 Patent DE679281 Methadone Patent DE865314 Patent DE870700 Patent DE890506 Justus Liebigs Ann. Chem. (1948) vol 561 p 52 - Post 483448 (Rhodium: "Bockmühl's Original Methadone Synthesis", Methods Discourse) racemate resolution: Patent US2644010 Patent US2983757 The Narcs



		Megatherium (Hive Bee) 10-23-03 22:38 No 466410				More analgesics (Rated as: good read)
						dextromethorphan Patent US2676177 Helv Acta (1951) vol 34 p 2211 dextromoramide Patent BE544757 Patent DE1117126 nor-methadone Patent DE865314 Patent DE870700 Justus Liebigs Ann Chem (1948) vol 561 p 52 - Post 483448 (Rhodium: "Bockmühl's Original Methadone Synthesis", Methods Discourse)

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