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All 5 posts Subject: Total Synthesis of Fentanyl Please login to post Down

thallium
(Newbee)
02-23-03 14:24
No 411081
      Total Synthesis of Fentanyl
(Rated as: excellent)

Arch. Pharm. Res. Vol.21, No. 1, pp. 70-72, 1998

Total Synthesis of Fentanyl

Young-Ger Suh, Kyung-Ho Cho and Dong-Yoon Shin
College of Pharmacy, Seoul National University, San 56-1, Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Korea
(Received November 15, 1997)

Fentanyl of a potent aniliodopiperidine analgesic has been synthesized from a simple phenyletylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenyletylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.

Key words : Fentanyl, Analgesics, Piperidine, Aminomethano desilyation-cyclization

INTRODUCTION

Fentanyl (1), a well known analgesic characterized by high potency, a rapid onset, and short duration of action belongs to a series of the 4-propionanilidopiperidines which represents a class of morphine-like analgesics (Janssen et al., 1968). In conjunction with development of novel anagesic agents, a series of work on the syntheses of fentanyl (Lednicer et al., 1977) and its structural analogues (Borne et al., 1984) have recently been carried out in our laboratory. More resently, we have also reported the excellent synthetic route to N-arylalkylpiperidines as a part of our successful results (Suh et al., 1997) and we herein report a total synthesis of fentanyl as a full paper in detail.

MATERIALS AND METHODS

Unless noted otherwise, all starting materials were obtained from commercial suppliers and were used without further purification. Tetrahydrofuran were distilled from sodium benzophenone ketyl. N,N-Dimethylformamide and dimethyl sulfoxide were distilled under reduced pressure from calcium hydride and stored over 4 Е molecular sieves under argon. Dichloromethane, triethylamine, benzene, toluene, and pyridine were freshly distilled from calcium hydride. Nitromethane was distilled and stored over calcium hydride under argon. All solvents used for routine isolation of products and chromatography were reagent grade and distilled. Reaction flasks were oven dried at 120°C. Air and moisture sensitive reactions were performed under an argon atmosphere. Flash chromatography was performed using silica gel 60 (230-400 mesh, Merck) with indicated solvents. Thin-layer chromatography was performed using 0.25 mm silica gel plates (Merck). Melting points were measured on a Büchi melting point apparatus and are uncorrected. Optical rotations were measured with JASCO DIP-1000 digital polarimeter at ambient temperature using 100 mm cell of 2 mL capacity. Infrared spectra were recorded on a Perkin-Elmer 1710 FT-IR spectrometer. Mass spectra obtained with VG Trio-2 GC-MS instrument. H and ¹³C NMR spectra were recorded on either a JEOL JNM-GCX 400 or JEOL JMN-LA 300 spectrometer as solutions in deuteriochloroform (CDCl₃). Chemical shifts are expressed in parts per million (ppm, δ) downfield from tetramethylsilane and are referenced to the deuterated solvent (CDCl₃). ¹H-NMR data are reported in the order of chemical shift, multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet and/or multiple ressonance), coupling constant in hertz (Hz), and number of protons.

4-Hydroxy-1-(2-phenylethyl)piperidine (2)

A heterogeneous mixture of allyltrimethylsilane (1.87 mL, 25 mmol), water (2.9 mL), phenylethylammonium trifluoroacetate (2.35 g, 10 mmol) and 37% aqueous formaldehyde (1.87 mL) in water was stirred at 58°C for 48 hours. Water was added and then the reaction mixture was alkalized with 1N NaOH and extracted with CH₂Cl₂. The organic extracts were washed with brine, dried over anhydrous MgSO₄ and evaporated to give white solid. The solid was recrystallized (EtOAc:n-Hexane) to give 1.30 g (63%) of white crystal. IR (KBr) cm^-1 3160; ¹H NMR (CDCl₃, 400 MHz) δ 7.39-7.21 (m, 5H), 3.78-3.73 (m, 1H), 2.90-2.81 (m, 4H), 2.68-2.60 (m, 2H), 2.28-2.23 (m, 2H), 1.99-1.94 (m, 2H), 1.76-1.61 (m, 2H); EIMS m/z 204 (M⁺-H), 114.

1-(2-Phenylethyl)-4-piperidone (6)

Oxalyl chloride (0.19 mL, 2.2 mmol) dissolved in CH₂Cl₂ (5 mL) was placed in a flask under nitrogen. The flask was cooled to -78°C and DMSO (0.34 mL, 4.8 mmol) in CH₂Cl₂ (1 mL) was added dropwise for about 5 min. Stirring was continued at -78°C for an additional 10 min followed by addition of the alcohol 3 (404 mg, 2 mmol) in CH₂Cl₂ (2 mL) for about 5 min. After aditional 15 min stirring, triethylamine (1.39 mL, 10 mmol) was added for about 5 min with stirring and then the reaction mixture was allowed to warm to room temperature. Water (15 mL) was added and the aqueous layer was reextracted with CH₂Cl₂ (50 mL). The organic layers were combined, washed with brine, and dried over anhydrous MgSO₄. The filtered solution was concentrated and the residue was purified by column chromatography (EtOAc:n-Hexane=2:1 with 0.5 v/v % NH₄OH) to give white solid (335 mg, 84%) IR (KBr) cm^-1 1720; ¹H NMR (CDCl₃, 400 MHz) δ 7.29-7.18 (m, 5H) 2.84-2.68 (m, 8H), 2.47-2.44 (m, 4H), EIMS m/z 203 (M⁺), 112.

4-anilino-1-(2-phenylethyl)piperidine (7)

A mixture of ketone 6 (100 mg, 0.49 mmol), aniline (45 mg, 0.49 mmol), and a catalytic amount of p-toluenesulfonic acid in toluene was stirred at reflux with removal of water by a Dean-Stark trap for 44 hours. The reactoun mixture was cooled and solvent was evaporated.

The resulting crude imine was dissolved in absolute ethanol (5 mL) and NaBH₄ (43 mg, 1.1 mmol) was added in a small portion. The mixture was stirred at 50°C for 14 hours and then quenched by addition of water. The mixture was diluted with CH₂Cl₂ and the organic layer was washed with water and brine, dried over anhydrous MgSO₄, evaporated and chromotographied (MeOH:CH₂Cl₂:acetone=1:30:20) to give white solid (85 mg, 62 %). ¹H NMR (CDCl₃, 400 MHz) δ 7.24-6.53 (m, 10H) 3.45 (bs, 1H), 3.29-3.23 (m, 1H), 2.91-2.54 (m, 6H), 2.18-1.40 (m, 6H); EIMS m/z 203 (M⁺), 189.

Alternative method for 7

PtO₂ was added to the imine in absolute ethanol and hydrogenated under hydrogen balloon. The reaction mixture was filtered through a celite bad, concentrated and chromatographied by the same procedure as above to give white solid.

N-(1-Phenylethyl-4-piperidyl)propionanilide (Fentanyl, 1)

To a toluene (20 mL) solution of piperidine 7 (100 mg, 0.36 mmol) was added 51 μL of propionic anhydride and the reaction mixture was stirred at reflux for 30 hours. After the addition of water (20 mL), the mixture was alkalized with c-NH₄OH and extracted with CH₂Cl₂. The organic layer was washed with brine, dried over anhydrous MgSO₄, filtered and concentrated to give 120 mg (100%) of white solid. IR (KBr) cm^-1 1650; ¹H NMR (CDCl₃, 400 MHz) δ 7.47-7.12 (m, 10H), 4.76-4.72 (m, 1H), 1.98 (q, 2H, J=7.2 Hz), 1.07 (t, 3H, J=7.2 Hz).

Video meliora proboque; Deteriora sequor. -Ovid

thallium
(Newbee)
02-23-03 14:27
No 411082
      RESULTS AND DISCUSSION Our synthetic approach...
(Rated as: good read)

RESULTS AND DISCUSSION

Our synthetic approach shown in scheme 1 involves an efficient construction of the piperidone skeleton via sequential aminomethano desilylation cyclization and oxidation of the resulting hydroxypiperidine (2) followed by introduction of propinoanilide side chain.

The intramolecular Mannich type cyclization as a key step of our synthesis was conducted as outlined in scheme 1 by reaction of trifluoroacetic acid salt 4 of the starting phenylethylamine with 1.1 equivalent of allyltrimethylsilane and 2.3 equivalent of 37% aqueous formaldehyde (Grieco et al., 1986, and Larson et al., 1986). The resulting 4-hydroxy-phenylethylpiperidine 2 was oxidiced to piperidone 6 for the introduction of aniline moiety. It should be noted that only Swern oxidation (Omura et al., 1978) was effective for oxidation of hydroxypiperidine 2. Reductive amination of piperidone 6 was achieved by an initial reaction with aniline and then NaBH₄ reduction. Finally, the synthesis was completed by the known acylation (Lendica et al., 1977) of anilinopiperidine 7 with propinic anhydride to afford the desired product which was identical in all aspects with the authentic fentanyl.

In conclusion, the total synthesis of fentanyl was accomplished by only four step reaction sequence. The key feature of this synthesis encludes the efficient construction of phenylethylpiperidine skeleton from phenylethylamine. Further synthetic applications of this route to the other aniliopiperidine analgesics and their analogues are in progress.

ACKNOWLEDGEMENT

We are grateful to TAI YANG Chemical Co. for support of this research.

REFERENCES CITED

Borne, R. P., Fifer, E. K. and Waters, I. W., Conformationally restrained fentanyl analogues., 2. Synthesis and analgesic evaluation of perhydro-1,6-naphtyridin-2-ones., J. Med. Chem., 27, 1271-1275 (1984) and references cited therein.

Janssen, P. J. A. and Van der Eycken, A. M., Drugs affecting the central nervous system, Burget, A. Ed., Marcel Dekker, New York, 1968, pp 51-54.

Grieco, P. A. and Fobare, W. F., Intramolecular variants of aminomethano desilylation: Reactions of in situ generated immonium ions with allylsilanes., Tetrahedron Lett., 27, 5067-5070 (1986).

Larsen, S. D., Grieco, P. A. and Fobare, W. F., Reactions of allylsilanes with simple iminium salts in water: A facile route to piperidines via an aminomethano desilylation-cyclixation prosess., J. Am. Chem. Soc., 108, 3512-3513 (1986).

Lednicer, D. and Mitscher, L. A., The organic chemistry of drug synthesis, John Wiley & Sons, New York, 1, pp 286-311 (1977).

Omura, K. and Swern, D., Oxidation of alcohols by "activated" dimethyl sulfoxide. A preparative steric and mechanistic study., Tetrahedron, 34 1651-1660 (1978).

Suh, Y.-G., Shin, D.-Y., Cho, K.-H. and Ryu, J.-S., Concise and versatile synthesis of N-arylalkylpiperidine as potential intermediates for 4-anilidopiperidine analgesics. Heterocycles, in press.

Video meliora proboque; Deteriora sequor. -Ovid

pHarmacist
(Hive Addict)
02-23-03 14:49
No 411086
User Picture       awesome work thallium, thank you!

but fix the link...

Accept No Imitations, There Can Only Bee One; www.the-hive.ws

Megatherium
(Hive Bee)
02-23-03 18:54
No 411131
      Stange

It is very peculiar that the yield for the acylation of (7) with propionic anhydride is so damned high. In earlier repports the yield of such a reaction almost never exceeds 60 %. Probably the high yield is due to the extended reaction time (30 freaking hours).

Notice that the above procedure yields the freebase. To get the crystalline .HCl salt (which is recommendable), one has to work up the reaction as follows:
1) after the acylation in refluxing toluene, let the flask cool and pour about 65 mL Et₂0 in the reaction mixture.
2) Place the flask in an ice bad and introduce HCl (g) in the mixture until no more .HCl salt precipitates.
3) Filter off the .HCl salt and wash it with cold Et₂0.
4) Recrystallize the .HCl salt from EtOH / EtOAc to obtain a white solid.

pHarmacist
(pHantasticant)
06-30-03 09:48
No 443473
User Picture       Two old, fentanyl-related Janssen patents:

Patent US3141823
Patent US3164600

Also, FR 2 430 M

Something like this:

1-benzyl-4-piperidone + aniline --LAH--> 4-anilino-1-benzylpiperidine

4-anilino-1-benzylpiperidine + propionic anhydride --H2/Pd-C--> N-(4-piperidyl)-propioanilide

N-(4-piperidyl)-propioanilide + 2-phenylethylchloride --Na2CO3--> Fentanyl

Accept No Imitations, There Can Only Bee One; www.the-hive.ws

	https://the-hive.archive.erowid.org	the-hive@erowid.org



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	All 5 posts		Subject: Total Synthesis of Fentanyl		Please login to post		Down


		thallium (Newbee) 02-23-03 14:24 No 411081				Total Synthesis of Fentanyl (Rated as: excellent)
						Arch. Pharm. Res. Vol.21, No. 1, pp. 70-72, 1998 Total Synthesis of Fentanyl Young-Ger Suh, Kyung-Ho Cho and Dong-Yoon Shin College of Pharmacy, Seoul National University, San 56-1, Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Korea (Received November 15, 1997) Fentanyl of a potent aniliodopiperidine analgesic has been synthesized from a simple phenyletylamine by four step sequence. The key part of this synthesis involves an efficient construction of phenyletylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation. Key words : Fentanyl, Analgesics, Piperidine, Aminomethano desilyation-cyclization INTRODUCTION Fentanyl (1), a well known analgesic characterized by high potency, a rapid onset, and short duration of action belongs to a series of the 4-propionanilidopiperidines which represents a class of morphine-like analgesics (Janssen et al., 1968). In conjunction with development of novel anagesic agents, a series of work on the syntheses of fentanyl (Lednicer et al., 1977) and its structural analogues (Borne et al., 1984) have recently been carried out in our laboratory. More resently, we have also reported the excellent synthetic route to N-arylalkylpiperidines as a part of our successful results (Suh et al., 1997) and we herein report a total synthesis of fentanyl as a full paper in detail. MATERIALS AND METHODS Unless noted otherwise, all starting materials were obtained from commercial suppliers and were used without further purification. Tetrahydrofuran were distilled from sodium benzophenone ketyl. N,N-Dimethylformamide and dimethyl sulfoxide were distilled under reduced pressure from calcium hydride and stored over 4 Е molecular sieves under argon. Dichloromethane, triethylamine, benzene, toluene, and pyridine were freshly distilled from calcium hydride. Nitromethane was distilled and stored over calcium hydride under argon. All solvents used for routine isolation of products and chromatography were reagent grade and distilled. Reaction flasks were oven dried at 120°C. Air and moisture sensitive reactions were performed under an argon atmosphere. Flash chromatography was performed using silica gel 60 (230-400 mesh, Merck) with indicated solvents. Thin-layer chromatography was performed using 0.25 mm silica gel plates (Merck). Melting points were measured on a Büchi melting point apparatus and are uncorrected. Optical rotations were measured with JASCO DIP-1000 digital polarimeter at ambient temperature using 100 mm cell of 2 mL capacity. Infrared spectra were recorded on a Perkin-Elmer 1710 FT-IR spectrometer. Mass spectra obtained with VG Trio-2 GC-MS instrument. H and ¹³C NMR spectra were recorded on either a JEOL JNM-GCX 400 or JEOL JMN-LA 300 spectrometer as solutions in deuteriochloroform (CDCl₃). Chemical shifts are expressed in parts per million (ppm, δ) downfield from tetramethylsilane and are referenced to the deuterated solvent (CDCl₃). ¹H-NMR data are reported in the order of chemical shift, multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet and/or multiple ressonance), coupling constant in hertz (Hz), and number of protons. 4-Hydroxy-1-(2-phenylethyl)piperidine (2) A heterogeneous mixture of allyltrimethylsilane (1.87 mL, 25 mmol), water (2.9 mL), phenylethylammonium trifluoroacetate (2.35 g, 10 mmol) and 37% aqueous formaldehyde (1.87 mL) in water was stirred at 58°C for 48 hours. Water was added and then the reaction mixture was alkalized with 1N NaOH and extracted with CH₂Cl₂. The organic extracts were washed with brine, dried over anhydrous MgSO₄ and evaporated to give white solid. The solid was recrystallized (EtOAc:n-Hexane) to give 1.30 g (63%) of white crystal. IR (KBr) cm^-1 3160; ¹H NMR (CDCl₃, 400 MHz) δ 7.39-7.21 (m, 5H), 3.78-3.73 (m, 1H), 2.90-2.81 (m, 4H), 2.68-2.60 (m, 2H), 2.28-2.23 (m, 2H), 1.99-1.94 (m, 2H), 1.76-1.61 (m, 2H); EIMS m/z 204 (M⁺-H), 114. 1-(2-Phenylethyl)-4-piperidone (6) Oxalyl chloride (0.19 mL, 2.2 mmol) dissolved in CH₂Cl₂ (5 mL) was placed in a flask under nitrogen. The flask was cooled to -78°C and DMSO (0.34 mL, 4.8 mmol) in CH₂Cl₂ (1 mL) was added dropwise for about 5 min. Stirring was continued at -78°C for an additional 10 min followed by addition of the alcohol 3 (404 mg, 2 mmol) in CH₂Cl₂ (2 mL) for about 5 min. After aditional 15 min stirring, triethylamine (1.39 mL, 10 mmol) was added for about 5 min with stirring and then the reaction mixture was allowed to warm to room temperature. Water (15 mL) was added and the aqueous layer was reextracted with CH₂Cl₂ (50 mL). The organic layers were combined, washed with brine, and dried over anhydrous MgSO₄. The filtered solution was concentrated and the residue was purified by column chromatography (EtOAc:n-Hexane=2:1 with 0.5 v/v % NH₄OH) to give white solid (335 mg, 84%) IR (KBr) cm^-1 1720; ¹H NMR (CDCl₃, 400 MHz) δ 7.29-7.18 (m, 5H) 2.84-2.68 (m, 8H), 2.47-2.44 (m, 4H), EIMS m/z 203 (M⁺), 112. 4-anilino-1-(2-phenylethyl)piperidine (7) A mixture of ketone 6 (100 mg, 0.49 mmol), aniline (45 mg, 0.49 mmol), and a catalytic amount of p-toluenesulfonic acid in toluene was stirred at reflux with removal of water by a Dean-Stark trap for 44 hours. The reactoun mixture was cooled and solvent was evaporated. The resulting crude imine was dissolved in absolute ethanol (5 mL) and NaBH₄ (43 mg, 1.1 mmol) was added in a small portion. The mixture was stirred at 50°C for 14 hours and then quenched by addition of water. The mixture was diluted with CH₂Cl₂ and the organic layer was washed with water and brine, dried over anhydrous MgSO₄, evaporated and chromotographied (MeOH:CH₂Cl₂:acetone=1:30:20) to give white solid (85 mg, 62 %). ¹H NMR (CDCl₃, 400 MHz) δ 7.24-6.53 (m, 10H) 3.45 (bs, 1H), 3.29-3.23 (m, 1H), 2.91-2.54 (m, 6H), 2.18-1.40 (m, 6H); EIMS m/z 203 (M⁺), 189. Alternative method for 7 PtO₂ was added to the imine in absolute ethanol and hydrogenated under hydrogen balloon. The reaction mixture was filtered through a celite bad, concentrated and chromatographied by the same procedure as above to give white solid. N-(1-Phenylethyl-4-piperidyl)propionanilide (Fentanyl, 1) To a toluene (20 mL) solution of piperidine 7 (100 mg, 0.36 mmol) was added 51 μL of propionic anhydride and the reaction mixture was stirred at reflux for 30 hours. After the addition of water (20 mL), the mixture was alkalized with c-NH₄OH and extracted with CH₂Cl₂. The organic layer was washed with brine, dried over anhydrous MgSO₄, filtered and concentrated to give 120 mg (100%) of white solid. IR (KBr) cm^-1 1650; ¹H NMR (CDCl₃, 400 MHz) δ 7.47-7.12 (m, 10H), 4.76-4.72 (m, 1H), 1.98 (q, 2H, J=7.2 Hz), 1.07 (t, 3H, J=7.2 Hz). Video meliora proboque; Deteriora sequor. -Ovid



		thallium (Newbee) 02-23-03 14:27 No 411082				RESULTS AND DISCUSSION Our synthetic approach... (Rated as: good read)
						RESULTS AND DISCUSSION Our synthetic approach shown in scheme 1 involves an efficient construction of the piperidone skeleton via sequential aminomethano desilylation cyclization and oxidation of the resulting hydroxypiperidine (2) followed by introduction of propinoanilide side chain. The intramolecular Mannich type cyclization as a key step of our synthesis was conducted as outlined in scheme 1 by reaction of trifluoroacetic acid salt 4 of the starting phenylethylamine with 1.1 equivalent of allyltrimethylsilane and 2.3 equivalent of 37% aqueous formaldehyde (Grieco et al., 1986, and Larson et al., 1986). The resulting 4-hydroxy-phenylethylpiperidine 2 was oxidiced to piperidone 6 for the introduction of aniline moiety. It should be noted that only Swern oxidation (Omura et al., 1978) was effective for oxidation of hydroxypiperidine 2. Reductive amination of piperidone 6 was achieved by an initial reaction with aniline and then NaBH₄ reduction. Finally, the synthesis was completed by the known acylation (Lendica et al., 1977) of anilinopiperidine 7 with propinic anhydride to afford the desired product which was identical in all aspects with the authentic fentanyl. In conclusion, the total synthesis of fentanyl was accomplished by only four step reaction sequence. The key feature of this synthesis encludes the efficient construction of phenylethylpiperidine skeleton from phenylethylamine. Further synthetic applications of this route to the other aniliopiperidine analgesics and their analogues are in progress. ACKNOWLEDGEMENT We are grateful to TAI YANG Chemical Co. for support of this research. REFERENCES CITED Borne, R. P., Fifer, E. K. and Waters, I. W., Conformationally restrained fentanyl analogues., 2. Synthesis and analgesic evaluation of perhydro-1,6-naphtyridin-2-ones., J. Med. Chem., 27, 1271-1275 (1984) and references cited therein. Janssen, P. J. A. and Van der Eycken, A. M., Drugs affecting the central nervous system, Burget, A. Ed., Marcel Dekker, New York, 1968, pp 51-54. Grieco, P. A. and Fobare, W. F., Intramolecular variants of aminomethano desilylation: Reactions of in situ generated immonium ions with allylsilanes., Tetrahedron Lett., 27, 5067-5070 (1986). Larsen, S. D., Grieco, P. A. and Fobare, W. F., Reactions of allylsilanes with simple iminium salts in water: A facile route to piperidines via an aminomethano desilylation-cyclixation prosess., J. Am. Chem. Soc., 108, 3512-3513 (1986). Lednicer, D. and Mitscher, L. A., The organic chemistry of drug synthesis, John Wiley & Sons, New York, 1, pp 286-311 (1977). Omura, K. and Swern, D., Oxidation of alcohols by "activated" dimethyl sulfoxide. A preparative steric and mechanistic study., Tetrahedron, 34 1651-1660 (1978). Suh, Y.-G., Shin, D.-Y., Cho, K.-H. and Ryu, J.-S., Concise and versatile synthesis of N-arylalkylpiperidine as potential intermediates for 4-anilidopiperidine analgesics. Heterocycles, in press. Video meliora proboque; Deteriora sequor. -Ovid



		pHarmacist (Hive Addict) 02-23-03 14:49 No 411086				awesome work thallium, thank you!
						but fix the link... Accept No Imitations, There Can Only Bee One; www.the-hive.ws



		Megatherium (Hive Bee) 02-23-03 18:54 No 411131				Stange
						It is very peculiar that the yield for the acylation of (7) with propionic anhydride is so damned high. In earlier repports the yield of such a reaction almost never exceeds 60 %. Probably the high yield is due to the extended reaction time (30 freaking hours). Notice that the above procedure yields the freebase. To get the crystalline .HCl salt (which is recommendable), one has to work up the reaction as follows: 1) after the acylation in refluxing toluene, let the flask cool and pour about 65 mL Et₂0 in the reaction mixture. 2) Place the flask in an ice bad and introduce HCl (g) in the mixture until no more .HCl salt precipitates. 3) Filter off the .HCl salt and wash it with cold Et₂0. 4) Recrystallize the .HCl salt from EtOH / EtOAc to obtain a white solid.



		pHarmacist (pHantasticant) 06-30-03 09:48 No 443473				Two old, fentanyl-related Janssen patents:
						Patent US3141823 Patent US3164600 Also, FR 2 430 M Something like this: 1-benzyl-4-piperidone + aniline --LAH--> 4-anilino-1-benzylpiperidine 4-anilino-1-benzylpiperidine + propionic anhydride --H2/Pd-C--> N-(4-piperidyl)-propioanilide N-(4-piperidyl)-propioanilide + 2-phenylethylchloride --Na2CO3--> Fentanyl Accept No Imitations, There Can Only Bee One; www.the-hive.ws

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