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All posts   Subject: Conformationally Restricted Fentanyl Analogs   Please login to post  

 
    pHarmacist
(Hive Addict)
05-28-03 17:56
No 436119
User Picture  		      Conformationally Restricted Fentanyl Analogs     

Bioorganic & Medicinal Chemistry Letters, Volume 5, Issue 11, 8 June 1995, Pages 1177-1182

Linas V. Kudzma, Suzanne M. Evans, Stanhope P. Turnbull, Jr. , Sherry A. Severnak and Edward F. Ezell

Abstract: Synthesis, analgesic activity and preliminary molecular modeling studies of the cis- and trans-fused octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines8 and 9, the first rigid fentanyl analogs with a conformationally restricted 4-anilido group that retain antinociceptive properties, are reported.

Full-Text: http://pharmacist8.tripod.com/restricted-fent.pdf
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