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	All 2 posts		Subject: Substituted N-Phenylpropanamides		Please login to post		Down

		pHarmacist (pHantasticant) 06-05-03 17:21 No 438010				Substituted N-Phenylpropanamides (Rated as: excellent)
						Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidyl]-N-phenylpropanamide and N-[3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide Willem F. M. Van Bever, Carlos J. E. Niemegeers, Paul A. J. Janssen; J. Med. Chem.; 1974; 17(10); 1047-1051. (https://www.rhodium.ws/pdf/fentanyl/3-methylfentanyl.diastereomers.pdf) Abstract: The synthesis of the respective diastereoisomers and enantiomers of N-[3-methyl-1-(2-phenylethyl)-4-piperidylj-N-phenylpropanamide and N-[3-methyl-l-(l-methyl-2-phenylethyl)-4-piperidyl]-N-phenylpropanamide is reported. Analgesic activity is evaluated in the tail withdrawal test in rats. cis-(+)-N-[3-Methyl-l-(2-phenylethyl)-4-piper-idyll-N-phenylpropanamide (23) is found to be an extremely potent analgesic, up to 6684 times morphine. Compound 23 has a fast onset of action, a shorter duration of action than morphine, and an unusually high safety margin. ____ ___ _ Janssen is the ultimate authority when it comes to synthing far-out potent opioids... Accept No Imitations, There Can Only Bee One; www.the-hive.ws
		murmur (HyperLab Bee) 06-09-03 08:57 No 438798				Janssen (Rated as: good read)
						There are some related patents: Patent US3907811 and Patent US3907813

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Date: 11-24-24, Release: 1.6 (10-04-15), Links: static, unique