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All 3 posts Subject: Synthesis of PMDEA Please login to post Down

Vibrating_Lights
(Hive Addict)
06-19-03 11:28
No 441002
      Synthesis of PMDEA

11ml diethylamine is dissolved in 30ml MeOh with 2 gms silica gel in an ice bath. then 10gms of PMP2P is alled and stirred for 1 hr. then .83 gms NaBH4 is added all at once and stirred for 20 hrs. 5ML GAA is added and solution is washed with 20mlDCM. Product basified with 10 ml25% Naoh An extracted with 30 ml EtAcOh 2x. theses extracts are dried and gassed with HCl to give 8gms P-Methoxyphenyl-2-diethylamine. Mp.Pending rextyl.
I wonder what this is going to do??

VL_

Start thinking more like a chemist and less like a criminal

Rhodium
(Chief Bee)
06-19-03 13:34
No 441009
User Picture       A cautionary note

Whatever it may do, be careful with the dosage - as you know, many mono-oxygenated amphetamines have significant pressor activity (i.e. increases heart rate and blood pressure) compared to their psychoactive effect - so a toxic dose may be lower than the dose needed to produce a significant psychoactive effect.

Other than this cautionary note, nice to see someone developing novel substances.

Vibrating_Lights
(Hive Addict)
06-19-03 21:13
No 441125
      Bioassay

Bioassay will come when optical isomers are isolated and analyzed with GC/MS. Will start bioassay at 250mcg. DEA stinks. easy synth though liquid amines are cool. Many twisted analogs to come since the DEA is requiring permits now.

Start thinking more like a chemist and less like a criminal

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	All 3 posts		Subject: Synthesis of PMDEA		Please login to post		Down


		Vibrating_Lights (Hive Addict) 06-19-03 11:28 No 441002				Synthesis of PMDEA
						11ml diethylamine is dissolved in 30ml MeOh with 2 gms silica gel in an ice bath. then 10gms of PMP2P is alled and stirred for 1 hr. then .83 gms NaBH4 is added all at once and stirred for 20 hrs. 5ML GAA is added and solution is washed with 20mlDCM. Product basified with 10 ml25% Naoh An extracted with 30 ml EtAcOh 2x. theses extracts are dried and gassed with HCl to give 8gms P-Methoxyphenyl-2-diethylamine. Mp.Pending rextyl. I wonder what this is going to do?? VL_ Start thinking more like a chemist and less like a criminal



		Rhodium (Chief Bee) 06-19-03 13:34 No 441009				A cautionary note
						Whatever it may do, be careful with the dosage - as you know, many mono-oxygenated amphetamines have significant pressor activity (i.e. increases heart rate and blood pressure) compared to their psychoactive effect - so a toxic dose may be lower than the dose needed to produce a significant psychoactive effect. Other than this cautionary note, nice to see someone developing novel substances.



		Vibrating_Lights (Hive Addict) 06-19-03 21:13 No 441125				Bioassay
						Bioassay will come when optical isomers are isolated and analyzed with GC/MS. Will start bioassay at 250mcg. DEA stinks. easy synth though liquid amines are cool. Many twisted analogs to come since the DEA is requiring permits now. Start thinking more like a chemist and less like a criminal

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