Hive Methods Discourse

	Main Index Search Register Login Who's Online FAQ Links
	Main Index Search Register Login Who's Online FAQ Links

	1 Online, 0 Active		You are not logged in

This is a historical archiveThe forum is read-only. Private information has been removed. It is not possible to login.

	Methods Discourse

All posts Subject: Novel Phenylcyclohexylamines.. Please login to post

Bwiti
(PVC-Analog Taste-Tester)
08-24-03 07:18
No 455365
User Picture Novel Phenylcyclohexylamines..

I found this interesting, so I decided to post it here:

4-(substituted alkoxy)-4-(substituted phenyl)cyclohexylamines

Patent US3965180

This invention relates to novel 4-(substituted alkoxy)-4-(substituted phenyl)cyclohexylamines embraced by the formula WHEREIN DIFFERENCE IS A GENERIC EXPRESSION DENOTING CIS AND TRANS STEREOCONFIGURATION AND MIXTURES THEREOF, WITH THE PROVISO THAT WHEN THE STEREOCONFIGURATION OF THE LINKAGE CONNECTING THE CYCLOHEXANE RING AND R3O is is cis to the amino group, the linkage connecting the cyclohexane and phenyl rings is always trans, and vice versa; R is selected from the group consisting of lower alkyl of 1 through 4 carbon atoms, chlorine, fluorine, bromine, trifluoromethyl, and lower alkoxy of 1 through 4 carbon atoms; R' has the same meaning as R and in addition hydrogen; R1 is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms; R2 is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms, ring monosubstituted aroylalkyl wherein the substituents have the same meaning as R and R', above, aryl is from 6 through 10 carbon atoms and alkyl of from 1 through 4 carbon atoms and bis (ring monosubstituted)arylalkyl wherein the substituents have the same meaning as R and R', above, aryl is from 6 through 10 carbon atoms and alkyl of from 1 through 4 carbon atoms; R1 and R2 taken together with -N< is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and monosubstituted pyrrolidino, piperidino, hexamethyleneimino, morpholino and piperazino; R3 is lower alkyl of 1 through 4 carbon atoms; and an acid addition salt thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (1) and novel derivatives thereof. The systemic administration to humans and animals of the novel compounds (1) depresses their central nervous systems.

Love my country, fear my government.

	https://the-hive.archive.erowid.org	the-hive@erowid.org



Powered by Tidal Power(R) Version 2.4.1, (C) 2015
Links Erowid Rhodium

	All posts		Subject: Novel Phenylcyclohexylamines..		Please login to post


		Bwiti (PVC-Analog Taste-Tester) 08-24-03 07:18 No 455365				Novel Phenylcyclohexylamines..
						I found this interesting, so I decided to post it here: 4-(substituted alkoxy)-4-(substituted phenyl)cyclohexylamines Patent US3965180 This invention relates to novel 4-(substituted alkoxy)-4-(substituted phenyl)cyclohexylamines embraced by the formula WHEREIN DIFFERENCE IS A GENERIC EXPRESSION DENOTING CIS AND TRANS STEREOCONFIGURATION AND MIXTURES THEREOF, WITH THE PROVISO THAT WHEN THE STEREOCONFIGURATION OF THE LINKAGE CONNECTING THE CYCLOHEXANE RING AND R3O is is cis to the amino group, the linkage connecting the cyclohexane and phenyl rings is always trans, and vice versa; R is selected from the group consisting of lower alkyl of 1 through 4 carbon atoms, chlorine, fluorine, bromine, trifluoromethyl, and lower alkoxy of 1 through 4 carbon atoms; R' has the same meaning as R and in addition hydrogen; R1 is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms; R2 is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms, ring monosubstituted aroylalkyl wherein the substituents have the same meaning as R and R', above, aryl is from 6 through 10 carbon atoms and alkyl of from 1 through 4 carbon atoms and bis (ring monosubstituted)arylalkyl wherein the substituents have the same meaning as R and R', above, aryl is from 6 through 10 carbon atoms and alkyl of from 1 through 4 carbon atoms; R1 and R2 taken together with -N< is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and monosubstituted pyrrolidino, piperidino, hexamethyleneimino, morpholino and piperazino; R3 is lower alkyl of 1 through 4 carbon atoms; and an acid addition salt thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (1) and novel derivatives thereof. The systemic administration to humans and animals of the novel compounds (1) depresses their central nervous systems. Love my country, fear my government.

	All posts		End of thread