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Methods Discourse | |
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All 10 posts | Subject: cocaine review | Please login to post | Down | |
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politoxicomania (Stranger) 09-07-03 22:33 No 457641 |
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cocaine review | ||||||
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After weeks in the lib. it seems to be the easyest way to cocaine: 2,5 dimethoxytetrahydrofuran to yield succinaldehyd succinaldehyd, MeNH3Cl and beta-ketoglutaric anhydride to yield d,l-2-Carbomethoxytropinone d and l 2-Carbomethyxytropinone via the Tartrates After NaBH4 and Benzoylation with Benoeacidanhydrid to yield (-)-cocaine Does anyone have some proofs for this reaktion ? Why only d,l-2-carbomethoxytropinone builds and not d,l-4-carbomethoxytropinone ? Hmm ? 
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politoxicomania (Stranger) 09-08-03 16:58 No 457733 |
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questiuon solved | ||||||
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question solved my yield of about 1 Mol (ca.300g) costs only 100€ exclusive Lab are the columbians still cheaper ?? 
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Vitus_Verdegast (Hive Bee) 09-08-03 17:02 No 457734 
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refs.. | ||||||
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Could you give the refs for your procedures? A Dream Within A Dream (http://www.poedecoder.com/Qrisse/works/dreamw.html) |
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politoxicomania (Stranger) 09-08-03 17:11 No 457735 |
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refs | ||||||
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Very good refs are: Ann. Chem. 111, 434 (1923) J. Am. Chem. Soc. 101, 2435-42 (1979) J. Org. Chem. 1389 (1957) Findlay J. Het. Chem. 24, 19-21 (1987) any questions? 
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roger2003 (Hive Bee) 09-08-03 17:57 No 457737 |
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cocaine | ||||||
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And your synthesis yields 300 g of the natural (-)isomer from the 8 possible isomers ? roger2003 |
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politoxicomania (Stranger) 09-08-03 18:20 No 457739 |
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cocaine | ||||||
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yes it is the (2R,3S)-3-Benzoyloxy-tropan-2-carbonacidmethylester |
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politoxicomania (Stranger) 09-08-03 18:27 No 457741 |
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cocaine | ||||||
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sorry have i mentioned this is only theorie of the reported yields in the refs |
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slappy (Hive Addict) 09-23-03 09:37 No 460526 |
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my yield of about 1 Mol (ca.300g) costs only... | ||||||
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my yield of about 1 Mol (ca.300g) costs only 100€ exclusive Lab are the columbians still cheaper ?? Ya, sounds great buddy! Let us know when you start your own cartel. Looks like someone needs to learn some basic organic stereochemistry. The d,l-tartrate resolution only resolves enantiomers, not diastereomers. So you are still left with 4 of the possible 8 isomers at the end, and you lose 50% of you material along the way. |
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roger2003 (Hive Bee) 09-23-03 12:54 No 460539 |
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yield | ||||||
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And the "over all yield" from succindialdehyde is about 10 % 
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politoxicomania (Stranger) 09-25-03 14:11 No 460984 |
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blabla | ||||||
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if there is someone who needs some lessons in organic chemistry it wont be me ..... iv send the chief bee a procedure to (-)cocaine from wich u will see the yield of 10 % (roger is right) is about 100€ per mol looking forward for the public procedure at rhodium to slappy: there are so many , many more intersting topics, and species who can give much more legal money and honer im just wondering why a very big german chemikal supplier, who produced cocaine in large quantities in the middle years of the last century wasnt be copied by anyone so far. Sure u will need a factory with 10-20 co-workers to produce in lucrative quantities, but who want to be a second escoba? or mess with Merck. ron |
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