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All 7 posts Subject: What is the purpose of DMF in electrosynth? Please login to post Down

ning
(Newbee)
09-10-03 17:28
No 458196
      What is the purpose of DMF in electrosynth?

I found a very sweet looking electrosynth of P2P from acetic anhydride and benzyl chloride just recently. (citation later, maybe you already have it? 1983 tetrahedron letters, french guys)

Anyway, it claims 50% yield using aluminum electrode and UNDIVIDED cell! 80% with magnesium.

Anyhow, since we all know how to get these precursors in a completely OTC manner, this method sounds very juicy. Only problem is, it seems to suggest using DMF as a solvent. What could the purpose of this be? I would very much like to substitute something more common. Is the DMF just to make the mixture conductive in an aprotic way? (?) So DMSO could be substituted, perhaps?

ning
(Newbee)
09-13-03 01:36
No 458774
      Helloooooooo.....!!?

Rhodium, terbium, anyone? Should I UTFSE? Is this paper already had? By the way, it was 1986, and here is the text:

ning
(Newbee)
09-13-03 01:39
No 458776
      Electrosynth of Ketones From Halides/Anhydrides
(Rated as: excellent)

Electrosynthesis of Ketones From Organic Halides and Anhydrides
by Esther d'INCAN, Soline SIBILLE, Jacques PERICHON
Laboratoire d'Electrochimie, Catalyse et Synthese Organique (U.M. n* 28)
Tetrahedron Letters 35, 4175-4176 (1986)

Abstract

The electroreduction of benzylic and allylic halides in the presence of anhydrides affords ketones in moderate to good yields. The electrolysis is performed in an undivided cell, under constant current, using an aluminum or magnesium anode.

Electroreductive acylation of halogen compounds should be an extremely useful tool for the synthesis of ketones. Benzylic halides have been reported to couple with aliphatic acid chlorides (1) or with acetic anhydride (2) by controlled-potential electrolysis in acetonitrile or DMF, using the standard two-compartments procedure. In previous communications, we reported that the use of sacraficial anodes of magnesium or duralumin in an undivided electrolytic cell enhanced the yield of coupling products between electrogenerated carbanions from organic halides and electrophiles such as carbon dioxide (3), ketones or aldehydes (4) in DMF. We wish now to report that allyl and benzylketones can be obtained by electroreduction of organic halides in DMF in the presence of anhydrides (5), by the same electrolytic procedure, according to :

RX + 2e^- --> R^- + X^-
Mg --> Mg²⁺ + 2e^-
R^- + R'COOCOR' --> RCOR' + R'CO₂^-

In a typical experiment, 30 mmoles of the halide, an excess of the anhydride and 1 mmole of tetrabutylammonium iodide or tetrafluoroborate as supporting electrolyte are dissolved in 25 ml of DMF. When acetic anhydride is the substrate, the solvent may even consist of a 4:1 mixture of anhydride and DMF. The cell is immersed in a cooling bath to keep the temperature of the electrolyte in the range of 0°C to 10°C. A constant current intensity (0.4 A) is applied between a rod of magnesium or duralumin (1 cm diameter) as the anode and a cylindrical grid of stainless steel or nickel (20 cm²) as the cathode, until 3 to 4 mole of electrons per mole of halide are passed. An acid hydrolysis (refluxing 1 h in H₂SO₄ 20%) destroys the excess of anhydride and releases the ketone from the enol ester which may be formed. After ether extraction, the ketone is purified by column chromatography or distillation and is identified by its spectral features (IR, ¹H-NMR).

Aliphatic anhydrides as well as benzoic anhydride, allylic and benzylic halides gave satisfactory results (Table I). This electrolytic procedure which needs only a current generator is specially easy to work up. It proved to be suitable for the preperation, with good yields, of benzylketones of synthetic utility in the field of pharmaceuticals or fragrances.

References:

1. T. Shono, I. Nishiguchi, H. Ohmizu. Chem. Lett., 1021, (1977)
2. J.P. Gisselbrecht, H. Lund. Acta Chem. Scand. Ser.B 39, 823, (1985)
3. O. Sock, M. Troupel, J. Perichon. Tetrahedron Let. 26, 1509, (1985)
4. S. Sibille, E. D'Incan, L. Leport, J. Perichon, Tetrahedron Let. (1986)
5. French Patent S.N.P.E. n* 85.047.42, (1985)

Table 1:

Electroreductive coupling of organic halides with anhydrides in DMF

Halide Anhydride    Anode Product (yield)
(mmoles) (mmoles)

C₆H₅CH₂Cl (30) CH₃COOCOCH₃   (300)   Mg    C₆H₅CH₂COCH3 (80%)
C₆H₅CH₂Cl (30) CH₃COOCOCH₃   (120)   Al    C₆H₅CH₂COCH₃ (50%)

C₆H₅CH₂Cl (30) C₂H₅COOCOC₂H₅ (150)   Mg    C6H5CH₂COCH₂CH₃ (75%)
C₆H₅CH₂Cl (30) C₆H₅COOCOC₆H₅ ( 40)   Mg    C₆H₅CH₂COC₆H₅   (80%)
....

ning
(Newbee)
09-16-03 19:13
No 459440
      found in....

Umm....let me see...This is from:
Tetrahedron Letters; 35; 1986; pp. 4175-4176

Found it on Beilstein. They synth a bunch of other intersting things, in varying yields.

ning
(Newbee)
10-01-03 02:20
No 461986
      Not to be rude, but....

Could some please answer the question I asked when I posted this paper? DMF is not easy to find. Is it necesary for this synthesis, and can it be substituted or omitted? DMSO? Acetone? Ethanol? Any ideas? Comments? Am I a moron for asking? Does anyone want to try this?

hypo
(Hive Addict)
10-01-03 07:36
No 462036
      try dmso

...

n'importe quoi

ning
(Newbee)
10-01-03 17:52
No 462105
      I just wonder

What the purpose is in the first place--they say that you can just use an excess of acetic anhydride as the solvent, but then recomend adding DMF to it. Is there a specific reason for this, I wonder?

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	All 7 posts		Subject: What is the purpose of DMF in electrosynth?		Please login to post		Down


		ning (Newbee) 09-10-03 17:28 No 458196				What is the purpose of DMF in electrosynth?
						I found a very sweet looking electrosynth of P2P from acetic anhydride and benzyl chloride just recently. (citation later, maybe you already have it? 1983 tetrahedron letters, french guys) Anyway, it claims 50% yield using aluminum electrode and UNDIVIDED cell! 80% with magnesium. Anyhow, since we all know how to get these precursors in a completely OTC manner, this method sounds very juicy. Only problem is, it seems to suggest using DMF as a solvent. What could the purpose of this be? I would very much like to substitute something more common. Is the DMF just to make the mixture conductive in an aprotic way? (?) So DMSO could be substituted, perhaps?



		ning (Newbee) 09-13-03 01:36 No 458774				Helloooooooo.....!!?
						Rhodium, terbium, anyone? Should I UTFSE? Is this paper already had? By the way, it was 1986, and here is the text:



		ning (Newbee) 09-13-03 01:39 No 458776				Electrosynth of Ketones From Halides/Anhydrides (Rated as: excellent)
						Electrosynthesis of Ketones From Organic Halides and Anhydrides by Esther d'INCAN, Soline SIBILLE, Jacques PERICHON Laboratoire d'Electrochimie, Catalyse et Synthese Organique (U.M. n* 28) Tetrahedron Letters 35, 4175-4176 (1986) Abstract The electroreduction of benzylic and allylic halides in the presence of anhydrides affords ketones in moderate to good yields. The electrolysis is performed in an undivided cell, under constant current, using an aluminum or magnesium anode. Electroreductive acylation of halogen compounds should be an extremely useful tool for the synthesis of ketones. Benzylic halides have been reported to couple with aliphatic acid chlorides (1) or with acetic anhydride (2) by controlled-potential electrolysis in acetonitrile or DMF, using the standard two-compartments procedure. In previous communications, we reported that the use of sacraficial anodes of magnesium or duralumin in an undivided electrolytic cell enhanced the yield of coupling products between electrogenerated carbanions from organic halides and electrophiles such as carbon dioxide (3), ketones or aldehydes (4) in DMF. We wish now to report that allyl and benzylketones can be obtained by electroreduction of organic halides in DMF in the presence of anhydrides (5), by the same electrolytic procedure, according to : RX + 2e^- --> R^- + X^- Mg --> Mg²⁺ + 2e^- R^- + R'COOCOR' --> RCOR' + R'CO₂^- In a typical experiment, 30 mmoles of the halide, an excess of the anhydride and 1 mmole of tetrabutylammonium iodide or tetrafluoroborate as supporting electrolyte are dissolved in 25 ml of DMF. When acetic anhydride is the substrate, the solvent may even consist of a 4:1 mixture of anhydride and DMF. The cell is immersed in a cooling bath to keep the temperature of the electrolyte in the range of 0°C to 10°C. A constant current intensity (0.4 A) is applied between a rod of magnesium or duralumin (1 cm diameter) as the anode and a cylindrical grid of stainless steel or nickel (20 cm²) as the cathode, until 3 to 4 mole of electrons per mole of halide are passed. An acid hydrolysis (refluxing 1 h in H₂SO₄ 20%) destroys the excess of anhydride and releases the ketone from the enol ester which may be formed. After ether extraction, the ketone is purified by column chromatography or distillation and is identified by its spectral features (IR, ¹H-NMR). Aliphatic anhydrides as well as benzoic anhydride, allylic and benzylic halides gave satisfactory results (Table I). This electrolytic procedure which needs only a current generator is specially easy to work up. It proved to be suitable for the preperation, with good yields, of benzylketones of synthetic utility in the field of pharmaceuticals or fragrances. References: 1. T. Shono, I. Nishiguchi, H. Ohmizu. Chem. Lett., 1021, (1977) 2. J.P. Gisselbrecht, H. Lund. Acta Chem. Scand. Ser.B 39, 823, (1985) 3. O. Sock, M. Troupel, J. Perichon. Tetrahedron Let. 26, 1509, (1985) 4. S. Sibille, E. D'Incan, L. Leport, J. Perichon, Tetrahedron Let. (1986) 5. French Patent S.N.P.E. n* 85.047.42, (1985) Table 1: Electroreductive coupling of organic halides with anhydrides in DMF Halide Anhydride Anode Product (yield) (mmoles) (mmoles) C₆H₅CH₂Cl (30) CH₃COOCOCH₃ (300) Mg C₆H₅CH₂COCH3 (80%) C₆H₅CH₂Cl (30) CH₃COOCOCH₃ (120) Al C₆H₅CH₂COCH₃ (50%) C₆H₅CH₂Cl (30) C₂H₅COOCOC₂H₅ (150) Mg C6H5CH₂COCH₂CH₃ (75%) C₆H₅CH₂Cl (30) C₆H₅COOCOC₆H₅ ( 40) Mg C₆H₅CH₂COC₆H₅ (80%) ....



		ning (Newbee) 09-16-03 19:13 No 459440				found in....
						Umm....let me see...This is from: Tetrahedron Letters; 35; 1986; pp. 4175-4176 Found it on Beilstein. They synth a bunch of other intersting things, in varying yields.



		ning (Newbee) 10-01-03 02:20 No 461986				Not to be rude, but....
						Could some please answer the question I asked when I posted this paper? DMF is not easy to find. Is it necesary for this synthesis, and can it be substituted or omitted? DMSO? Acetone? Ethanol? Any ideas? Comments? Am I a moron for asking? Does anyone want to try this?



		hypo (Hive Addict) 10-01-03 07:36 No 462036				try dmso
						... n'importe quoi



		ning (Newbee) 10-01-03 17:52 No 462105				I just wonder
						What the purpose is in the first place--they say that you can just use an excess of acetic anhydride as the solvent, but then recomend adding DMF to it. Is there a specific reason for this, I wonder?

All 7 posts	End of thread	Top