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All 2 posts Subject: 2-Amino-5-substituted oxazolines and intermediates Please login to post Down

Vitus_Verdegast
(Hive Bee)
09-30-03 20:20
No 461942
User Picture       2-Amino-5-substituted oxazolines and intermediates
(Rated as: excellent)

2-Amino-5-substituted oxazolines and intermediates as potential anorectants.
Freiter, Edward R.; Abdallah, Abdulmunien H.; Strycker, Stanley J.
Journal of Medicinal Chemistry 16(5), 510-12 (1973) (https://www.rhodium.ws/pdf/2-amino-5-arylthiomethyloxazolines.pdf)
CAN 79:61392, AN 1973:461392

Abstract

2-Amino-5-arylthiomethyl-2-oxazolines and their intermediates 1-amino-3-arylthio-2-propanols showed significant anorectant activity but were less active than d-amphetamine. The most active compd. in the series was 2-amino-5-(phenylthiomethyl)-2-oxazoline (I) [41136-03-2], which at 46 mg/kg orally decreased food intake by mice by 62% in the 1st hr after administration. To synthesize I, thiophenol [108-98-5] was reacted with epichlorohydrin [106-89-8] in the presence of NaOH, and the resulting epoxide was reacted with NH₃ to yield 1-amino-3-phenylthio-2-propanol [35550-43-7], which was reacted the CNBr and cyclized to I.

A Dream Within A Dream (http://www.poedecoder.com/Qrisse/works/dreamw.html)

Rhodium
(Chief Bee)
09-30-03 22:47
No 461958
User Picture       Just for TFSE-Technical Reasons...

I uploaded the article in PDF format to my page and linked it from whitin your post, so that we have both the citation/abstract and the link in the same post wink

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	All 2 posts		Subject: 2-Amino-5-substituted oxazolines and intermediates		Please login to post		Down


		Vitus_Verdegast (Hive Bee) 09-30-03 20:20 No 461942				2-Amino-5-substituted oxazolines and intermediates (Rated as: excellent)
						2-Amino-5-substituted oxazolines and intermediates as potential anorectants. Freiter, Edward R.; Abdallah, Abdulmunien H.; Strycker, Stanley J. Journal of Medicinal Chemistry 16(5), 510-12 (1973) (https://www.rhodium.ws/pdf/2-amino-5-arylthiomethyloxazolines.pdf) CAN 79:61392, AN 1973:461392 Abstract 2-Amino-5-arylthiomethyl-2-oxazolines and their intermediates 1-amino-3-arylthio-2-propanols showed significant anorectant activity but were less active than d-amphetamine. The most active compd. in the series was 2-amino-5-(phenylthiomethyl)-2-oxazoline (I) [41136-03-2], which at 46 mg/kg orally decreased food intake by mice by 62% in the 1st hr after administration. To synthesize I, thiophenol [108-98-5] was reacted with epichlorohydrin [106-89-8] in the presence of NaOH, and the resulting epoxide was reacted with NH₃ to yield 1-amino-3-phenylthio-2-propanol [35550-43-7], which was reacted the CNBr and cyclized to I. A Dream Within A Dream (http://www.poedecoder.com/Qrisse/works/dreamw.html)



		Rhodium (Chief Bee) 09-30-03 22:47 No 461958				Just for TFSE-Technical Reasons...
						I uploaded the article in PDF format to my page and linked it from whitin your post, so that we have both the citation/abstract and the link in the same post

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