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All 6 posts Subject: Methysticins methylenedioxyphenyl moiety n2 MDA? Please login to post Down

quaero_quero61
(Stranger)
10-04-03 17:56
No 462582
      Methysticins methylenedioxyphenyl moiety n2 MDA?

Can't help but notice the methylenedioxyphenyl moiety on the Methysticin component of Kava Kava.Hours of checking TFSE and the net but to no avail. Anybees no of a way of using this in an MDA MDMA synth??

I searched the world over and thought I'd found true love....

terbium
(Old P2P Cook)
10-04-03 18:25
No 462587
      Methylenedioxy everywhere, but not a drop to drink

You could oxidize it to piperonal but this would not likely be easy for the average underground chemist. If one were going to do this then piperic acid from pepper would probably being a more conveniently obtained starting material than methysticin.

The 1-alkyl-3,4-methylenedioxybenzene moiety is not uncommon in nature. It is also found in some plant lignins and production of piperonal from pulping of these lignins may also have been discussed here.

The next problem is that once you have piperonal, the most direct route to MDA or MDMA requires nitroethane which is difficult to acquire.

All those moments will be lost in time, like tears in rain.

GC_MS
(Hive Addict)
10-05-03 09:07
No 462694
User Picture       Phenylpropanoids
(Rated as: good read)

The synthesis of phenylpropanoids makes part of the shikimic acid pathway. Phenylpropanoids with 4-OH, 4-OMe, 3-MeO-4-OH, 3,4-MeOH, 3,4-OH are very common. Methylenedioxyrings are less common but usually can still be found in a majority of plants. However, not all substances bearing methylenedioxyrings can be used as piperonal/(iso)safrole precursor, since methylenedioxy-bearing compounds are often applied as (neo)lignane, alkaloid, flavanoid, ... construction block. Go to a library and look for books on plant biosynthesis and the like. Going through these books for a handful of hours is usually enough to understand it is not as easy as 1-2-3... wink

Shikimic acid pathway:

Biosynthesis of methylchavicol/eugenol in sweet basil:

3,5-diMeO-4-OH is also very common... wink

Advanced clitoris massage specialist. 32 years of experience. PM me for a "sample".

quaero_quero61
(Stranger)
10-08-03 00:11
No 463281
      Methylenedioxy and Methysticin

Thanks Terbium and GC_MS for your responses! I guess my Question was too simplistic. Bee nice if MDA or MDMA were possible from methysticin but I realize there are easier ways. I was really thinking more along the lines of increasing activity of the methysticin by addition. In a paper Shulgin wrote for the UN ODC in 1973 {Issue 2-007}Shulgin mentions additions made on the ethylene bridge between the two rings has led to no increase in potency.Further he mentions, "Homologues of mythysticin have been studied as well. The substitution of a variety of groups on the tertiary carbon connecting the ethylene link with the dihydropyrone ring, yielded compounds without pharmacological interest. On the other hand, the replacement of the methoxy- group of methysticin with an ethoxy group (ethysticin) seems to provide an active material [4] that has been studied in man." I am unable to find the study he mentions and wondered what the effects of this ethysticin are. I am also curious of any other research being conducted on Kavalactones if any bee could please point a novice in the right direction!?
Love Kava already but interested in ways of possibly improving it.
By the way in a dream the traditional Kava drink prepared with several grams of added GHB was highly enjoyable, as well as pain relieving!!

In the midnight hour she cried MORE MORE MORE!

SPISSHAK
(Hive Addict)
10-08-03 02:01
No 463298
      you are confusing chemical cousins here.

you are asking advice on two diferent chemical classes, A: the kavalactones and thier ring expansion derivatives and then you want input on ring substituted phenylethyl (or phenyl-iso-propylamines), we chem heads like to expound on one class at a time in order to fully dissect your curiousity.
take your inquiries in order please?

quaero_quero61
(Stranger)
10-08-03 02:47
No 463307
      Not confused just ignorant

Spisshack I'm not confused just ignorant and not a chemist. I full well realize Methysticin is composed of a Methylenedioxy connected with a lactone.Shoot take your pick I'm just interested in any work being done or knowledge on souping this thing up from either end!

Livin after Midnight Rockin to the dawn lovin till the morning....

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	All 6 posts		Subject: Methysticins methylenedioxyphenyl moiety n2 MDA?		Please login to post		Down


		quaero_quero61 (Stranger) 10-04-03 17:56 No 462582				Methysticins methylenedioxyphenyl moiety n2 MDA?
						Can't help but notice the methylenedioxyphenyl moiety on the Methysticin component of Kava Kava.Hours of checking TFSE and the net but to no avail. Anybees no of a way of using this in an MDA MDMA synth?? I searched the world over and thought I'd found true love....



		terbium (Old P2P Cook) 10-04-03 18:25 No 462587				Methylenedioxy everywhere, but not a drop to drink
						You could oxidize it to piperonal but this would not likely be easy for the average underground chemist. If one were going to do this then piperic acid from pepper would probably being a more conveniently obtained starting material than methysticin. The 1-alkyl-3,4-methylenedioxybenzene moiety is not uncommon in nature. It is also found in some plant lignins and production of piperonal from pulping of these lignins may also have been discussed here. The next problem is that once you have piperonal, the most direct route to MDA or MDMA requires nitroethane which is difficult to acquire. All those moments will be lost in time, like tears in rain.



		GC_MS (Hive Addict) 10-05-03 09:07 No 462694				Phenylpropanoids (Rated as: good read)
						The synthesis of phenylpropanoids makes part of the shikimic acid pathway. Phenylpropanoids with 4-OH, 4-OMe, 3-MeO-4-OH, 3,4-MeOH, 3,4-OH are very common. Methylenedioxyrings are less common but usually can still be found in a majority of plants. However, not all substances bearing methylenedioxyrings can be used as piperonal/(iso)safrole precursor, since methylenedioxy-bearing compounds are often applied as (neo)lignane, alkaloid, flavanoid, ... construction block. Go to a library and look for books on plant biosynthesis and the like. Going through these books for a handful of hours is usually enough to understand it is not as easy as 1-2-3... Shikimic acid pathway: Biosynthesis of methylchavicol/eugenol in sweet basil: 3,5-diMeO-4-OH is also very common... Advanced clitoris massage specialist. 32 years of experience. PM me for a "sample".



		quaero_quero61 (Stranger) 10-08-03 00:11 No 463281				Methylenedioxy and Methysticin
						Thanks Terbium and GC_MS for your responses! I guess my Question was too simplistic. Bee nice if MDA or MDMA were possible from methysticin but I realize there are easier ways. I was really thinking more along the lines of increasing activity of the methysticin by addition. In a paper Shulgin wrote for the UN ODC in 1973 {Issue 2-007}Shulgin mentions additions made on the ethylene bridge between the two rings has led to no increase in potency.Further he mentions, "Homologues of mythysticin have been studied as well. The substitution of a variety of groups on the tertiary carbon connecting the ethylene link with the dihydropyrone ring, yielded compounds without pharmacological interest. On the other hand, the replacement of the methoxy- group of methysticin with an ethoxy group (ethysticin) seems to provide an active material [4] that has been studied in man." I am unable to find the study he mentions and wondered what the effects of this ethysticin are. I am also curious of any other research being conducted on Kavalactones if any bee could please point a novice in the right direction!? Love Kava already but interested in ways of possibly improving it. By the way in a dream the traditional Kava drink prepared with several grams of added GHB was highly enjoyable, as well as pain relieving!! In the midnight hour she cried MORE MORE MORE!



		SPISSHAK (Hive Addict) 10-08-03 02:01 No 463298				you are confusing chemical cousins here.
						you are asking advice on two diferent chemical classes, A: the kavalactones and thier ring expansion derivatives and then you want input on ring substituted phenylethyl (or phenyl-iso-propylamines), we chem heads like to expound on one class at a time in order to fully dissect your curiousity. take your inquiries in order please?



		quaero_quero61 (Stranger) 10-08-03 02:47 No 463307				Not confused just ignorant
						Spisshack I'm not confused just ignorant and not a chemist. I full well realize Methysticin is composed of a Methylenedioxy connected with a lactone.Shoot take your pick I'm just interested in any work being done or knowledge on souping this thing up from either end! Livin after Midnight Rockin to the dawn lovin till the morning....

All 6 posts	End of thread	Top