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All 4 posts Subject: Novel Route to convert Hydroxylimide to Ketamine!! Please login to post Down

k0dog
(Hive Bee)
10-05-03 19:01
No 462771
      Novel Route to convert Hydroxylimide to Ketamine!!

Now first off I must say that I am not sure at all about the accountability of the rest of the post. These were ideas that I got last night after reading through old chemistry papers that I had laying on the floor...The one that This is concerning was: https://www.rhodium.ws/pdf/solventfree.kmno4.oxidation.pdf

Now in this publish it says "...arenes (the generic name for monocyclic and/or polycyclic aromatic hydrocarbon) are oxidized to the corresponding alpha-ketones..."

This leads me to believe that this methode of oxidazation could possibly be used as an alternative to a thermal re-arrangement via reflux or pressure bomb. I have no creditable datum to really support my argument but it does seem like the following will occure:

Hydroxylimide
Molecule: Hydroxylimide (" C\N=C(\c1ccccc1Cl)C2(O)CCCC2 ")
^__>
Step #1
Molecule: Step1 (" C\N=C(\c1ccccc1Cl)[C-]2(=O)CCCC2 ")
^__>
Step #2
Molecule: Step2 (" C2CCC[C-](=N\C)(\c1c(Cl)cccc1)C2=O ")
^__>
Ketamine
Molecule: Ketamine (" C1(\c2ccccc2Cl)(N/C)CCCCC1=O ")

*N.B. The C- should be in red or something so that they highlight the fact taht Carbon will not stay in this state long!
**N.B. The ketamine molecule should have an electron beside it, that was liberated from the Pi bond between the [Carbon]^-1 and the amino group

My questions are as follows:
1) Will the oxidation of this "Arene" go as I have posted above?
2) The Hydroxyl group cannot be oxidized because of the carbon that it is attached to already has 4 bonds. If it does not go as shown above how and what does this reaction do?
3) If anyone has any ideas about a novel route to convert hydroxylimide to ketamine please post it here!!! I will love you forever!!!

Thanks for reading and I sure hope that I posted this forum in the right place, because it could also go in newbees.. but it is a bit to complicated for the.... Also could have maybe gone in General discourse.. but I'm confident that I made the right decision... lol... tongue

P.S. I Have now master the art of using SMILE diagram thingys.... I will hopefully never have as much trouble with this as before... It's cuz Chemsketch doesn't use normal Smile Coding always.. like it does but it arranges it very bizare... and I Had trouble getting the grasp of it.. but now I'm good... anwyas Anyone any Thoughts on my cool idea?

"Vanity is defintely my favourite sin"
-Devil's advocate

Rhodium
(Chief Bee)
10-05-03 23:01
No 462800
User Picture       unintelligible SMILES code

You have written unintelligible SMILES code in your post, so it doesn't render correctly. First of all, you are not allowed to place random spaces in the [mol] tags nor in the SMILES code itself, which is also incorrect, as there are several unclosed rings in your code. How on earth did you create the SMILES strings? Use a SMILES-compatible editor if you are unable to do it yourself.

Lilienthal
(Moderator)
10-06-03 08:37
No 462923
User Picture       Carbon atoms with five bonds are impossible.

Carbon atoms with five bonds are impossible. Forget it.

k0dog
(Hive Bee)
10-06-03 16:33
No 462986
      OK... this thread can be closed and deleted..

OK... this thread can be closed and deleted.. cuz I screwed up so much!!! I freaking was thinking at all.. There is not even a spare electron to donate to the oxidization... What the hell!!! I then freaking got so work up and trying to use this SMILE code that I finally did it.. After countless hours of not sleeping and attempts.. I then opted for the help.. and easy as Pie I understood it... grrrr...

OK.. So can a Moderator please either delete or close this thread... I hope delete cuz I made a freakin' ass out of myself... wow I am dumb sometimes...

Peace...
BTW: I am expecting a BAD KARMA rating cuz... not only was I completely DUMB.. but I just ranted... but hey...thats Life in the-Hive.ws

"Vanity is defintely my favourite sin"
-Devil's advocate

	https://the-hive.archive.erowid.org	the-hive@erowid.org



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	All 4 posts		Subject: Novel Route to convert Hydroxylimide to Ketamine!!		Please login to post		Down


		k0dog (Hive Bee) 10-05-03 19:01 No 462771				Novel Route to convert Hydroxylimide to Ketamine!!
						Now first off I must say that I am not sure at all about the accountability of the rest of the post. These were ideas that I got last night after reading through old chemistry papers that I had laying on the floor...The one that This is concerning was: https://www.rhodium.ws/pdf/solventfree.kmno4.oxidation.pdf Now in this publish it says "...arenes (the generic name for monocyclic and/or polycyclic aromatic hydrocarbon) are oxidized to the corresponding alpha-ketones..." This leads me to believe that this methode of oxidazation could possibly be used as an alternative to a thermal re-arrangement via reflux or pressure bomb. I have no creditable datum to really support my argument but it does seem like the following will occure: Hydroxylimide Molecule: Hydroxylimide (" C\N=C(\c1ccccc1Cl)C2(O)CCCC2 ") ^__> Step #1 Molecule: Step1 (" C\N=C(\c1ccccc1Cl)[C-]2(=O)CCCC2 ") ^__> Step #2 Molecule: Step2 (" C2CCC[C-](=N\C)(\c1c(Cl)cccc1)C2=O ") ^__> Ketamine Molecule: Ketamine (" C1(\c2ccccc2Cl)(N/C)CCCCC1=O ") N.B. The C- should be in red or something so that they highlight the fact taht Carbon will not stay in this state long! *N.B. The ketamine molecule should have an electron beside it, that was liberated from the Pi bond between the [Carbon]^-1 and the amino group My questions are as follows: 1) Will the oxidation of this "Arene" go as I have posted above? 2) The Hydroxyl group cannot be oxidized because of the carbon that it is attached to already has 4 bonds. If it does not go as shown above how and what does this reaction do? 3) If anyone has any ideas about a novel route to convert hydroxylimide to ketamine please post it here!!! I will love you forever!!! Thanks for reading and I sure hope that I posted this forum in the right place, because it could also go in newbees.. but it is a bit to complicated for the.... Also could have maybe gone in General discourse.. but I'm confident that I made the right decision... lol... P.S. I Have now master the art of using SMILE diagram thingys.... I will hopefully never have as much trouble with this as before... It's cuz Chemsketch doesn't use normal Smile Coding always.. like it does but it arranges it very bizare... and I Had trouble getting the grasp of it.. but now I'm good... anwyas Anyone any Thoughts on my cool idea? "Vanity is defintely my favourite sin" -Devil's advocate



		Rhodium (Chief Bee) 10-05-03 23:01 No 462800				unintelligible SMILES code
						You have written unintelligible SMILES code in your post, so it doesn't render correctly. First of all, you are not allowed to place random spaces in the [mol] tags nor in the SMILES code itself, which is also incorrect, as there are several unclosed rings in your code. How on earth did you create the SMILES strings? Use a SMILES-compatible editor if you are unable to do it yourself.



		Lilienthal (Moderator) 10-06-03 08:37 No 462923				Carbon atoms with five bonds are impossible.
						Carbon atoms with five bonds are impossible. Forget it.



		k0dog (Hive Bee) 10-06-03 16:33 No 462986				OK... this thread can be closed and deleted..
						OK... this thread can be closed and deleted.. cuz I screwed up so much!!! I freaking was thinking at all.. There is not even a spare electron to donate to the oxidization... What the hell!!! I then freaking got so work up and trying to use this SMILE code that I finally did it.. After countless hours of not sleeping and attempts.. I then opted for the help.. and easy as Pie I understood it... grrrr... OK.. So can a Moderator please either delete or close this thread... I hope delete cuz I made a freakin' ass out of myself... wow I am dumb sometimes... Peace... BTW: I am expecting a BAD KARMA rating cuz... not only was I completely DUMB.. but I just ranted... but hey...thats Life in the-Hive.ws "Vanity is defintely my favourite sin" -Devil's advocate

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