|
Main Index Search Register Login Who's Online FAQ Links | |
||
|
|
|||
|
||||
| 2 Online, 0 Active | You are not logged in | |||
|
|
Methods Discourse | |
|
|
|
|
All 3 posts | Subject: Hydrocodone | Please login to post | Down | |
|||
|
|
|
|
|
|||||||
|
roddyjojo (Stranger) 11-30-03 08:50 No 473856 |
|
Hydrocodone | ||||||
|
https://www.rhodium.ws/chemistry/dihydromorphinones.html Regarding the text available at the posted link, and the codeine -> dihydrocodeinone (hydrocodone) by rearrangement, can Nickel (Nickel metal or Nickel on Aluminum) be used in place of Pd/Pt in this reaction? I've read somewhere that it can but at some sacrifice to yields, however cannot recall the source. Also if a powdered mixture of Nickel and Copper and roughly evening amounts was used, how would the presence of the Copper affect the reaction? Thanks |
||||||||
|
|
|||||||
|
|
|
|||||||
|
bouncer (Stranger) 12-12-03 01:37 No 476268 |
|
Has anyone done such synth: codeine ->... | ||||||
|
Has anyone done such synth: codeine -> dihydrocodeinone (hydrocodone) ? It seems as it would be very mg efficient (less hydrocodone is needed than codeine to achieve euphoria) |
||||||||
|
|
|||||||
|
|
|
|||||||
|
algebra (Hive Bee) 12-12-03 04:01 No 476299 
|
|
No - do more reading... | ||||||
|
No - do more reading... LoneR says that Pd in dry toluene (rather than acidic aqueous solution) yeilds 30% (see alt.d.c). note even rapoport was apparently unable to replicate this hydrogenation/dehydrogenation to obtain the hydrogenated ketone with any kind of yield. |
||||||||
|
|
|||||||