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All 4 posts Subject: Methamphetamines via acetaldehyde methylimine Please login to post Down

Bandil
(The Archetypical "Good Guy")
01-23-04 12:19
No 484172
      Methamphetamines via acetaldehyde methylimine

Hi bees!

Chose not to post this in the stimulant forum, as the method looks usable for a great deal of compounds aswell.

This (https://www.rhodium.ws/chemistry/grignardimine.html) method on Rhodiums page looks quite nice, but i cant quite figure out how the reaction actually works with all the water formed in the acetaldehyde methylimine intermediate. The author does not use any form of drying techniques for getting rid of his mole of water formed? As far as i have understood things the water will utterly ruin the benzylmagnesiumchloride. Maybe the imine does react with the magnesiumchloride and is directly turned into methamphetamine by the water present?

Can anyone enlighten me here, as i am somewhat confused about the reaction!

Thanks!

Regards
Bandil

Edit: whops, forgot to post the link im talking about... This has now been corrected.

Drugs = Fun; Drugs <> Money

Vitus_Verdegast
(Hive Addict)
01-23-04 13:32
No 484181
User Picture       here is some info:

I think that the guy has exaggerated his success somewhat, especially as you look at Vera Evdokimoff's original article which gave only 40% yield using MeNH2 freebase and Na2SO4 as drying agent. But now in the age of molecular sieves that yield should easily be exceeded.
Post 450065 (Rhodium: "grignard on acetaldehyde methylimine -> meth", Stimulants)

also read:
Post 248673 (Rhodium: "Re: Novel BzCl To Meth In One Pot", Chemistry Discourse)
Post 378668 (Rhodium: "acetaldehyde methylimine", Stimulants)

acetaldehyde methylimine will polymerize easily:
Post 18586 (Rhodium: "Re: a revolution in amphetamine synthesis ??", Chemistry Discourse)
Post 16488 (Rhodium: "Clandestine lab survey report", General Discourse)

Edward Bernays, "Propaganda" (1928) (http://www.igpub.com/propaganda.html)

Bandil
(The Archetypical "Good Guy")
01-23-04 13:58
No 484183
      Thanks!

Thanks Vitus, you rock!

Regards
Bandil

Drugs = Fun; Drugs <> Money

Rhodium
(Chief Bee)
01-23-04 16:21
No 484193
User Picture       grignard reagents as un-cheap drying agents

Also note that two equivalents of BnMgCl is used in Vera's original article - some of the 100% excess reagent is probably used as an expensive 'drying agent' - any formed toluene is removed in the workup.

^{The Hive - Clandestine Chemists Without Borders}

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	All 4 posts		Subject: Methamphetamines via acetaldehyde methylimine		Please login to post		Down


		Bandil (The Archetypical "Good Guy") 01-23-04 12:19 No 484172				Methamphetamines via acetaldehyde methylimine
						Hi bees! Chose not to post this in the stimulant forum, as the method looks usable for a great deal of compounds aswell. This (https://www.rhodium.ws/chemistry/grignardimine.html) method on Rhodiums page looks quite nice, but i cant quite figure out how the reaction actually works with all the water formed in the acetaldehyde methylimine intermediate. The author does not use any form of drying techniques for getting rid of his mole of water formed? As far as i have understood things the water will utterly ruin the benzylmagnesiumchloride. Maybe the imine does react with the magnesiumchloride and is directly turned into methamphetamine by the water present? Can anyone enlighten me here, as i am somewhat confused about the reaction! Thanks! Regards Bandil Edit: whops, forgot to post the link im talking about... This has now been corrected. Drugs = Fun; Drugs <> Money



		Vitus_Verdegast (Hive Addict) 01-23-04 13:32 No 484181				here is some info:
						I think that the guy has exaggerated his success somewhat, especially as you look at Vera Evdokimoff's original article which gave only 40% yield using MeNH2 freebase and Na2SO4 as drying agent. But now in the age of molecular sieves that yield should easily be exceeded. Post 450065 (Rhodium: "grignard on acetaldehyde methylimine -> meth", Stimulants) also read: Post 248673 (Rhodium: "Re: Novel BzCl To Meth In One Pot", Chemistry Discourse) Post 378668 (Rhodium: "acetaldehyde methylimine", Stimulants) acetaldehyde methylimine will polymerize easily: Post 18586 (Rhodium: "Re: a revolution in amphetamine synthesis ??", Chemistry Discourse) Post 16488 (Rhodium: "Clandestine lab survey report", General Discourse) Edward Bernays, "Propaganda" (1928) (http://www.igpub.com/propaganda.html)



		Bandil (The Archetypical "Good Guy") 01-23-04 13:58 No 484183				Thanks!
						Thanks Vitus, you rock! Regards Bandil Drugs = Fun; Drugs <> Money



		Rhodium (Chief Bee) 01-23-04 16:21 No 484193				grignard reagents as un-cheap drying agents
						Also note that two equivalents of BnMgCl is used in Vera's original article - some of the 100% excess reagent is probably used as an expensive 'drying agent' - any formed toluene is removed in the workup. ^{The Hive - Clandestine Chemists Without Borders}

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