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All 6 posts | Subject: Extraction of safrole from sassafras oil | Please login to post | Down | |
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claude (Stranger) 07-16-04 11:32 No 519742 |
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Extraction of safrole from sassafras oil | ||||||
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Hi, I'm new here, but I would like to have your opinion concerning the following procedure of safrole extraction : In sassafras oil, we find in various proportions, depending on the oil's origin : - Safrole - Pinene - Phellandrene - Camphor - Eugenol According to the CRC Handbook of Chemistry : Water Ethanol Safrole insoluble very soluble Pinene insoluble soluble Phellandrene insoluble insoluble Camphor slightly soluble very soluble Eugenol slightly soluble ? So, if the oil is first repeatedly washed with water, eugenol and camphor will be extracted from the oil. Then, if the oil if treated with ethanol, nearly all safrole and some pinene can be extracted, leaving the phellandrene. Yes, the purity of safrole isn't perfect, there is residual pinene, but can this procedure be an alternative to freezing or distilling sassatras oil ? For those like me :( who doesn't have low pressure distillation material, and aren't lucky in fractionally freezing the oil. And maybe a further crystallisation will work now, and achieve the purification of safrole ? claude |
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Nicodem (Hive Bee) 07-16-04 12:58 No 519747 
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There is a thing called the partition coefficient | ||||||
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…and its value is not in favor of your proposal. You should first ask yourself what "slightly soluble" means. You can't efficiently extract something that is much, much more soluble in non-polar solvents with water. Utmost you could extract eugenol with aqueous NaOH, but not camphor or anything else from your list. “The real drug-problem is that we need more and better drugs.” – J. Ott |
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armageddon 07-16-04 21:27 |
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(Rated as: redundant) |
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ApprenticeCook (Hive Bee) 07-18-04 10:01 No 520057 |
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Dont know how much purer it seems to get it... | ||||||
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Dont know how much purer it seems to get it but for piece of mind swim does this.... Freeze and extract safrole+whatever crystals (this is done 4 times) then distill and collect the safrole fraction bp, freeze again and then distilled again to collect the safrole fraction bp again. For isomerisation in the high end conversion yields the safrole needs to be super pure, doing the above method gets iso conversion of 95-97% with no probs. -AC Its just my opinion, but no-one listens to me anyway, and rightly so... |
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icexool (Stranger) 07-21-04 15:47 No 520625 |
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brazillian sassafras oil | ||||||
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Today I went to a store and asked if they could order sassafras oil from china(I've heard that's 96% safrole) Anyway they came up saying they did however could order brazillian sassafras oil. It might be helpfull for others. I'm 99% sure this can be used since it contains that much safrole: Botanic: ocotea pretiosa Nees Family: lauraceae Used part: Wood Ingredients: 0,7% alpha-pineen phellandreen 5% cadineen 0,6% eugenol 75-95% safrol 0,2% 1,8-cineol 1-4% kamfer *source Franchomme et al., o.c Sjankara |
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XrLeap (Newbee) 07-22-04 21:37 No 520886 |
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emm... simple distillation does not mess up... | ||||||
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emm... simple distillation does not mess up the whole thing, just about 1 to 2 percent of polymerized crap that could be cleaned easily with acetone. just try it with simple distillation.:) oops i did it again |
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