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All 3 posts Subject: Chlorine instead of Br in Ketamine and PPA Synths Please login to post Down

wolff_kishner
(Stranger)
07-23-04 20:35
No 521165
      Chlorine instead of Br in Ketamine and PPA Synths

Is chlorine an acceptable substitute for bromine in the following syntheses?

1. Bromination of o-chlorophenyl cyclopentyl ketone (Ketamine synthesis)

2. alpha bromination of propiophenone (PPA synthesis from propiophenone)

The nature of the reactions seems to indicate that any halogen will do. Am I wrong? Is bromine specifically required?

starlight
(Hive Bee)
07-23-04 22:36
No 521190
      I would imagine

That if you made alpha-chloro propiophenone you would get close to no yield when trying to substitute the halogen with ammonia.

Organikum
(Wonderful Personality)
07-24-04 04:04
No 521253
      It might work using a pressure bomb, though.

It might work using a pressure bomb, though.

Schnabufugl!

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	All 3 posts		Subject: Chlorine instead of Br in Ketamine and PPA Synths		Please login to post		Down


		wolff_kishner (Stranger) 07-23-04 20:35 No 521165				Chlorine instead of Br in Ketamine and PPA Synths
						Is chlorine an acceptable substitute for bromine in the following syntheses? 1. Bromination of o-chlorophenyl cyclopentyl ketone (Ketamine synthesis) 2. alpha bromination of propiophenone (PPA synthesis from propiophenone) The nature of the reactions seems to indicate that any halogen will do. Am I wrong? Is bromine specifically required?



		starlight (Hive Bee) 07-23-04 22:36 No 521190				I would imagine
						That if you made alpha-chloro propiophenone you would get close to no yield when trying to substitute the halogen with ammonia.



		Organikum (Wonderful Personality) 07-24-04 04:04 No 521253				It might work using a pressure bomb, though.
						It might work using a pressure bomb, though. Schnabufugl!

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