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All 3 posts Subject: Essential Opioids Please login to post Down

thallium
(Hive Bee)
07-28-04 23:19
No 522315
User Picture       Essential Opioids

Synthesis and Analgetic Activities of Some Aminobenzylcyclanols Derived from Menthone
Özarslan, Ц. et al.
Arch. Pharm. (Weinheim) 327, 525-528 (1994)

Abstract:

Several cyclohexanamines such as Tilidin, Tramadol, and Ciramadol have been used as opiate analgesic drugs. Here, we describe synthesis and analgesic activity of some aminocyclanols from (-)-menthone (1R,4S-1-methyl-4-isopropyl-cyclohexan-3-one).

Two synthetic routes are described for the preparation of amino-benzylcyclanols and related derivates: One is the reaction of alpha-benzylcyclanols. In the other approach, benzisoxazols are first formed from benzylnitrones and cycloalkene, then treatment of benzisoxazoles with an allyl-halide produces the corresponding benzoxazoline halide and hydrogenolysis of these halides give the desired compounds.

(Used TFSE for this one too, and couldn't find it. Hoping it's not hidden somewhere deep inside the hive...)

Video meliora, proboque; Deteriora sequor. -Ovid

starlight
(Hive Bee)
07-29-04 10:42
No 522433
      that looks easy

Intersting to read that with some of the synthesized compounds, if they are administered for 5 days and then the animals are subjected to a naloxone challenge there is no withdrawal.

Does anybody know if it is likely that these compounds have any euphoriant qualities? Is it likely that those that do not induce withdrawal are not as euphoric (just skeptical as you rarely get something for nothing in this world).

Dope_Amine
(Hive Bee)
08-20-04 02:03
No 526383
User Picture       Benzomorphans do not have nearly the physical...

Benzomorphans do not have nearly the physical addiction potential and they can be very fun~ phenazocine, metazocine....

I'd really like to experiment with O-acetyl phenazocine one day. I've heard conflicting arguements on whether it would have any difference in effect.

(Hi y'all, it's been a while....)

something for your mind.......

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	All 3 posts		Subject: Essential Opioids		Please login to post		Down


		thallium (Hive Bee) 07-28-04 23:19 No 522315				Essential Opioids
						Synthesis and Analgetic Activities of Some Aminobenzylcyclanols Derived from Menthone Özarslan, Ц. et al. Arch. Pharm. (Weinheim) 327, 525-528 (1994) Abstract: Several cyclohexanamines such as Tilidin, Tramadol, and Ciramadol have been used as opiate analgesic drugs. Here, we describe synthesis and analgesic activity of some aminocyclanols from (-)-menthone (1R,4S-1-methyl-4-isopropyl-cyclohexan-3-one). Two synthetic routes are described for the preparation of amino-benzylcyclanols and related derivates: One is the reaction of alpha-benzylcyclanols. In the other approach, benzisoxazols are first formed from benzylnitrones and cycloalkene, then treatment of benzisoxazoles with an allyl-halide produces the corresponding benzoxazoline halide and hydrogenolysis of these halides give the desired compounds. (Used TFSE for this one too, and couldn't find it. Hoping it's not hidden somewhere deep inside the hive...) Video meliora, proboque; Deteriora sequor. -Ovid



		starlight (Hive Bee) 07-29-04 10:42 No 522433				that looks easy
						Intersting to read that with some of the synthesized compounds, if they are administered for 5 days and then the animals are subjected to a naloxone challenge there is no withdrawal. Does anybody know if it is likely that these compounds have any euphoriant qualities? Is it likely that those that do not induce withdrawal are not as euphoric (just skeptical as you rarely get something for nothing in this world).



		Dope_Amine (Hive Bee) 08-20-04 02:03 No 526383				Benzomorphans do not have nearly the physical...
						Benzomorphans do not have nearly the physical addiction potential and they can be very fun~ phenazocine, metazocine.... I'd really like to experiment with O-acetyl phenazocine one day. I've heard conflicting arguements on whether it would have any difference in effect. (Hi y'all, it's been a while....) something for your mind.......

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