Hive General Discourse

	Main Index Search Register Login Who's Online FAQ Links
	Main Index Search Register Login Who's Online FAQ Links

	2 Online, 0 Active		You are not logged in

This is a historical archiveThe forum is read-only. Private information has been removed. It is not possible to login.

	General Discourse

All posts Subject: Acute and chronic effects of TRY and alcohol Please login to post

meme
(Hive Bee)
08-20-04 20:10
No 526508
Acute and chronic effects of TRY and alcohol

Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats

http://www.ingenta.com/isis/browsing/TOC/ingenta%3Bjsessionid=cl1vhpg8otls.circus?issue=infobike%3A//vsp/ba/2004/00000018/F0040003 pp. 291-306(16)

K. Hoshi; M. Hayashi; T. Bandoh

Abstract:
The present review will concentrate on a discussion of recent investigations that demonstrated whether the levels of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in the locus coeruleus are influenced by tryptophan alone or simultaneous administration of tryptophan and ethanol. The impetus for this line of investigation derives from a report that mice treated with tryptophol plus alcohol increased brain tryptophol level and became highly susceptible to convulsions. A deficiency in 5-HT synthesis and metabolism (turnover) has been implicated in several neuropsychiatric disorders, including depression, obsessive-compulsive disorder, bulimia nervosa, late luteal phase dysphoric syndrome, alcoholism, impulsive violence and aggression. Emphasis will be placed on demonstration of a rodent model in which the tryptophan administration induces the increased 5-HIAA level through the activation of serotonergic neuronal system. The use of in vivo microdialysis techniques clearly identifies, in this model, that acutely- or consecutively-treated tryptophan plus ethanol results in focal increases in extracellular levels of 5-HIAA within the locus coeruleus. This study provides evidence to indicate that the 5-HIAA level in the locus coeruleus after tryptophan alone or tryptophan plus ethanol is indicative of changes in the activity of serotonergic neurotransmission in locus coeruleus neurons and the participation of 5-HIAA as a general phenomenon in behavioral activation.

Keywords: LOCUS COERULEUS; DORSAL RAPHE NUCLEUS; TRYPTOPHAN; 5-HIAA; 5-HYDROXYINDOLEACETIC ACID; ALCOHOL; MICRODIALYSIS

Document Type: Research article ISSN: 0168-8561

SICI (online): 0168-8561(20040601)18:3L.291;1-

	https://the-hive.archive.erowid.org	the-hive@erowid.org



Powdered by Mr Hyde Release 6.09.3, © 2022-2023, Good Vibrations Industries
Links Erowid Rhodium

	All posts		Subject: Acute and chronic effects of TRY and alcohol		Please login to post


		meme (Hive Bee) 08-20-04 20:10 No 526508				Acute and chronic effects of TRY and alcohol
						Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats http://www.ingenta.com/isis/browsing/TOC/ingenta%3Bjsessionid=cl1vhpg8otls.circus?issue=infobike%3A//vsp/ba/2004/00000018/F0040003 pp. 291-306(16) K. Hoshi; M. Hayashi; T. Bandoh Abstract: The present review will concentrate on a discussion of recent investigations that demonstrated whether the levels of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in the locus coeruleus are influenced by tryptophan alone or simultaneous administration of tryptophan and ethanol. The impetus for this line of investigation derives from a report that mice treated with tryptophol plus alcohol increased brain tryptophol level and became highly susceptible to convulsions. A deficiency in 5-HT synthesis and metabolism (turnover) has been implicated in several neuropsychiatric disorders, including depression, obsessive-compulsive disorder, bulimia nervosa, late luteal phase dysphoric syndrome, alcoholism, impulsive violence and aggression. Emphasis will be placed on demonstration of a rodent model in which the tryptophan administration induces the increased 5-HIAA level through the activation of serotonergic neuronal system. The use of in vivo microdialysis techniques clearly identifies, in this model, that acutely- or consecutively-treated tryptophan plus ethanol results in focal increases in extracellular levels of 5-HIAA within the locus coeruleus. This study provides evidence to indicate that the 5-HIAA level in the locus coeruleus after tryptophan alone or tryptophan plus ethanol is indicative of changes in the activity of serotonergic neurotransmission in locus coeruleus neurons and the participation of 5-HIAA as a general phenomenon in behavioral activation. Keywords: LOCUS COERULEUS; DORSAL RAPHE NUCLEUS; TRYPTOPHAN; 5-HIAA; 5-HYDROXYINDOLEACETIC ACID; ALCOHOL; MICRODIALYSIS Document Type: Research article ISSN: 0168-8561 SICI (online): 0168-8561(20040601)18:3L.291;1-

	All posts		End of thread