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All 4 posts Subject: ethamivan Please login to post Down

stratosphere
(Hive Bee)
09-10-04 23:22
No 530707
      ethamivan

i was wondering if anybody had any subjective knowledge on the effects of ethamivan.
most information i find seems to state it is a cns +respritory stimulant. i find it somewhat surprising it would have any cns activity considering it has a 4-hydroxy-phenyl group.

methyl_ethyl
(Guardian)
09-11-04 01:23
No 530736
User Picture       CNS

From what I have read this drug is not a CNS stimulant, it also does not selectively stimulate respiratory neurons, however it may stimulate pulmonary "chemoreflexes" which may be the reason it is called a respiratory stimulant, however that being said literature states that an increase in repiratory rate was noted but not an increase in tidal volume. I have not heard of anything stating it's action as a "true" CNS stimulant. Where did you find information stating it's use as a CNS stimulant?

I personally have never heard of this drug and just did a quick medline search on it.

Respiratory stimulant effects of ethamivan and picrotoxin.
Hirsh K, Wang SC.
Pharmacol Exp Ther. 1975 May;193(2):657-63.
Medline (PMID=1173598)

Judging by the literature, this drug was hot in the sixties, and people kind of lost interest. There is probably a good reason for this smile

regards,

methyl_ethyl

   Unipolar Mania, It's good for life... laugh

stratosphere
(Hive Bee)
09-11-04 03:13
No 530773
      i saw a number of pages which sort of implied...

i saw a number of pages which sort of implied it was a cns stimulant but most of these where of questionable reliability.
one that i saw which seemed credible was
http://xoomer.virgilio.it/medicine/drugsnervous.html
if you scroll way down to psycho stimulants it has ethamivan listed there under a catergory of "inhibiting inhibitory circuits, along with several other drugs such as doxapram, mefexamide.

Fastandbulbous
(Hive Bee)
09-11-04 14:03
No 530846
User Picture       Actions

Most of the pharmacology text books I've got state that it's a respiratory stimulant that is actually a convulsant at higher doses (similar to begramide and pentylenetetrazole), but say nothing about it being a psychostimulant or increasing locomotor activity.

Personally, I would give it a wide berth unless someone had personal experience of it's actions

That is right, the Mascara Snake: Fast and bulbous

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		stratosphere (Hive Bee) 09-10-04 23:22 No 530707				ethamivan
						i was wondering if anybody had any subjective knowledge on the effects of ethamivan. most information i find seems to state it is a cns +respritory stimulant. i find it somewhat surprising it would have any cns activity considering it has a 4-hydroxy-phenyl group.



		methyl_ethyl (Guardian) 09-11-04 01:23 No 530736				CNS
						From what I have read this drug is not a CNS stimulant, it also does not selectively stimulate respiratory neurons, however it may stimulate pulmonary "chemoreflexes" which may be the reason it is called a respiratory stimulant, however that being said literature states that an increase in repiratory rate was noted but not an increase in tidal volume. I have not heard of anything stating it's action as a "true" CNS stimulant. Where did you find information stating it's use as a CNS stimulant? I personally have never heard of this drug and just did a quick medline search on it. Respiratory stimulant effects of ethamivan and picrotoxin. Hirsh K, Wang SC. Pharmacol Exp Ther. 1975 May;193(2):657-63. Medline (PMID=1173598) Judging by the literature, this drug was hot in the sixties, and people kind of lost interest. There is probably a good reason for this regards, methyl_ethyl Unipolar Mania, It's good for life...



		stratosphere (Hive Bee) 09-11-04 03:13 No 530773				i saw a number of pages which sort of implied...
						i saw a number of pages which sort of implied it was a cns stimulant but most of these where of questionable reliability. one that i saw which seemed credible was http://xoomer.virgilio.it/medicine/drugsnervous.html if you scroll way down to psycho stimulants it has ethamivan listed there under a catergory of "inhibiting inhibitory circuits, along with several other drugs such as doxapram, mefexamide.



		Fastandbulbous (Hive Bee) 09-11-04 14:03 No 530846				Actions
						Most of the pharmacology text books I've got state that it's a respiratory stimulant that is actually a convulsant at higher doses (similar to begramide and pentylenetetrazole), but say nothing about it being a psychostimulant or increasing locomotor activity. Personally, I would give it a wide berth unless someone had personal experience of it's actions That is right, the Mascara Snake: Fast and bulbous

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