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	Tryptamine Chemistry

All 11 posts Subject: AET microwave synhtesis Please login to post Down

onlynikud
(Stranger)
09-21-04 20:00
No 532552
      AET microwave synhtesis

I found this in this forum:

I have a question regarding a possibly easy synth for AET. Here's Hest's microwave synth for AMT:

500mg indole-3-carboxaldehyde was mixed with 1g nitroethane and 50mg amm.acetate. The mixture was nuked with 150W for 2min, and then rextalised from methanol.
Yeald: >90%

Do you think using the same process but using nitropropane instead of nitroethane might result in AET rather than AMT? What would you come up with if you used nitrobutane or nitromethane?

answer:

...he reaction with nitropropane will work, yielding AET..

... AET would have a yield around 40%, and much less for APT, etc....

my (newbie) questions are:

1. Could I put three chemicals togheter, 500mg indole-3-carboxaldehyde, 1g nitropropane, 50mg amm.acetate, in a common glass then I nuke it with 150w in a common microwave and i get 40% AET

2. if i would get 40% AET, what could i do to make it ingestible, it is not necessary to get crystal or pure only it should not be poissonous and make me high

Ne deutsche Antwort würde ich besser verstehen. I understand only elementary English

Lestat
(Hive Bee)
09-21-04 23:32
No 532589
User Picture       I found a possible useful synthesis for ...

I found a possible useful synthesis for indole-3-carboxaldehyde via skatole (4-methylindole) using an enzyme from pseudomonas bacteria.

Over unity and rivers of blood for all!

hest
(Hive Adickt)
09-22-04 06:39
No 532644
      Re: 1. Could I put three chemicals togheter,...

1. Could I put three chemicals togheter, 500mg indole-3-carboxaldehyde, 1g nitropropane, 50mg amm.acetate, in a common glass then I nuke it with 150w in a common microwave and i get 40% AET
I'm sure it will work
But you have to do som workup after, A/B ect.

Lestat
(Hive Bee)
09-22-04 07:08
No 532647
User Picture       Starting from indole, methylation via MeI does

Starting from indole, methylation via MeI does its thing at the 3 position, then resulting 3-methylindole (skatole) is further attacked to produce 3,3-dimethylindolenine.

Is there any practical way to protect the skatole, ensuring attack ceased once that stage had been reached?

What about using either DMF or dimethyl sulfate, or bis(2-chloromethyl)sulfide (a methyl analogue of sulfur mustard) as the methylating agent?

SWIM has beecome really interested in this synthesis as of late you see smile

Over unity and rivers of blood for all!

onlynikud
(Stranger)
09-22-04 20:19
No 532734
      Extraction

3-idolaldehyde is to heavy for me to synthesize, but very interesting when i got more knowledge. but i do not believe that this Chem is watched?

does sombody have a exact and sure way, how to get the stuff, as powder or something else consumeble

Ne deutsche Antwort würde ich besser verstehen.

hest
(Hive Adickt)
09-23-04 08:21
No 532807
      A-mt

http://www.erowid.org/library/books_online/tihkal/tihkal48.shtml Iff this is to hard to doo, just by the chemical from Aldric ect.

Trenchcoat
(Hive Bee)
09-23-04 09:14
No 532809
User Picture       LAH and THF

Aren't LAH and THF difficult to obtain and even more difficult to work with for people with less-than-stellar labratory skills? Is such a one-pot-shot microwave synthesis of aMT possible or was that just speculation? I couldn't tell by the style of his writing.

Better loving through chemistry.

hest
(Hive Adickt)
09-23-04 09:18
No 532810
      red

You will produce the nitrostyrene, and yes you have to reduce this one with LAH.
I just asumed that he knew that, but your right, after reading the post again I'm in doubht.

starlight
(Hive Bee)
09-23-04 09:25
No 532812
      AET is not easy

The nitrobutene is hard to make in good yield, and the nitrobutane is pretty unstable to heat.

Post 514779 (starlight: "Satisfactory condensation method", Tryptamine Chemistry)
Post 515154 (starlight: "Sensitive molecule - beware", Tryptamine Chemistry)

if you are a beginner, I recommend you start with something else (most things here are easier than this).

onlynikud
(Stranger)
09-23-04 10:30
No 532816
      i am not sure,

fuuuuuuuuuuuuuuuuck

i got only the precursor "1-(3-indolyl)-2-nitrobutene-1"
but i need "3-(2-AMINOBUTYL)INDOLE"

Ne deutsche Antwort würde ich besser verstehen.

hest
(Hive Adickt)
09-23-04 12:28
No 532828
      Yes

Yes and this nice speciem you rextalise, and reduce with one of the manye wayes describet at the hive (LAH/NaBH4+PTC/NaBH4+Al/Zn AcOH) ect.

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	All 11 posts		Subject: AET microwave synhtesis		Please login to post		Down


		onlynikud (Stranger) 09-21-04 20:00 No 532552				AET microwave synhtesis
						I found this in this forum: I have a question regarding a possibly easy synth for AET. Here's Hest's microwave synth for AMT: 500mg indole-3-carboxaldehyde was mixed with 1g nitroethane and 50mg amm.acetate. The mixture was nuked with 150W for 2min, and then rextalised from methanol. Yeald: >90% Do you think using the same process but using nitropropane instead of nitroethane might result in AET rather than AMT? What would you come up with if you used nitrobutane or nitromethane? answer: ...he reaction with nitropropane will work, yielding AET.. ... AET would have a yield around 40%, and much less for APT, etc.... my (newbie) questions are: 1. Could I put three chemicals togheter, 500mg indole-3-carboxaldehyde, 1g nitropropane, 50mg amm.acetate, in a common glass then I nuke it with 150w in a common microwave and i get 40% AET 2. if i would get 40% AET, what could i do to make it ingestible, it is not necessary to get crystal or pure only it should not be poissonous and make me high Ne deutsche Antwort würde ich besser verstehen. I understand only elementary English



		Lestat (Hive Bee) 09-21-04 23:32 No 532589				I found a possible useful synthesis for ...
						I found a possible useful synthesis for indole-3-carboxaldehyde via skatole (4-methylindole) using an enzyme from pseudomonas bacteria. Over unity and rivers of blood for all!



		hest (Hive Adickt) 09-22-04 06:39 No 532644				Re: 1. Could I put three chemicals togheter,...
						1. Could I put three chemicals togheter, 500mg indole-3-carboxaldehyde, 1g nitropropane, 50mg amm.acetate, in a common glass then I nuke it with 150w in a common microwave and i get 40% AET I'm sure it will work But you have to do som workup after, A/B ect.



		Lestat (Hive Bee) 09-22-04 07:08 No 532647				Starting from indole, methylation via MeI does
						Starting from indole, methylation via MeI does its thing at the 3 position, then resulting 3-methylindole (skatole) is further attacked to produce 3,3-dimethylindolenine. Is there any practical way to protect the skatole, ensuring attack ceased once that stage had been reached? What about using either DMF or dimethyl sulfate, or bis(2-chloromethyl)sulfide (a methyl analogue of sulfur mustard) as the methylating agent? SWIM has beecome really interested in this synthesis as of late you see Over unity and rivers of blood for all!



		onlynikud (Stranger) 09-22-04 20:19 No 532734				Extraction
						3-idolaldehyde is to heavy for me to synthesize, but very interesting when i got more knowledge. but i do not believe that this Chem is watched? does sombody have a exact and sure way, how to get the stuff, as powder or something else consumeble Ne deutsche Antwort würde ich besser verstehen.



		hest (Hive Adickt) 09-23-04 08:21 No 532807				A-mt
						http://www.erowid.org/library/books_online/tihkal/tihkal48.shtml Iff this is to hard to doo, just by the chemical from Aldric ect.



		Trenchcoat (Hive Bee) 09-23-04 09:14 No 532809				LAH and THF
						Aren't LAH and THF difficult to obtain and even more difficult to work with for people with less-than-stellar labratory skills? Is such a one-pot-shot microwave synthesis of aMT possible or was that just speculation? I couldn't tell by the style of his writing. Better loving through chemistry.



		hest (Hive Adickt) 09-23-04 09:18 No 532810				red
						You will produce the nitrostyrene, and yes you have to reduce this one with LAH. I just asumed that he knew that, but your right, after reading the post again I'm in doubht.



		starlight (Hive Bee) 09-23-04 09:25 No 532812				AET is not easy
						The nitrobutene is hard to make in good yield, and the nitrobutane is pretty unstable to heat. Post 514779 (starlight: "Satisfactory condensation method", Tryptamine Chemistry) Post 515154 (starlight: "Sensitive molecule - beware", Tryptamine Chemistry) if you are a beginner, I recommend you start with something else (most things here are easier than this).



		onlynikud (Stranger) 09-23-04 10:30 No 532816				i am not sure,
						fuuuuuuuuuuuuuuuuck i got only the precursor "1-(3-indolyl)-2-nitrobutene-1" but i need "3-(2-AMINOBUTYL)INDOLE" Ne deutsche Antwort würde ich besser verstehen.



		hest (Hive Adickt) 09-23-04 12:28 No 532828				Yes
						Yes and this nice speciem you rextalise, and reduce with one of the manye wayes describet at the hive (LAH/NaBH4+PTC/NaBH4+Al/Zn AcOH) ect.

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