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|Subject: Selegiline (MAOB inhibiton) and Tryptamines
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|Selegiline (MAOB inhibiton) and Tryptamines
Here is actually a question i always had but received no answer no matter how hard i looked.
It can be summarized in this two sentences
1)Would the coadministration of a MAOB inhibitor such as Selegiline (deprenyl) at low dose (5mg) qualitatively or quantitatively alter a tryptamine experience,and if so how?
2)Would the coadministation of the aforementioned inhibitor with an ayahuasca mixture qualitatively or quantitatively alter the experience and if so how? Notice that ayahuasca contains a MAOA inhibitor.
What follows is a post i made some time ago that got no answer and shows my train of though in a more detailed way.
|Moclobemide != Deprenyl
|oooops my mistake!
Im sorry for the grave mistake ,i was thinking of SELEGILINE (Deprenyl) and wrote MOCLIBEMIDE (Aurorix).Excuse me for the mix up but it was a time of the night that my mind simply turned into porridge!
The question though still stands...MAOB Inhibition via Selegiline + Tryptamines = ?
(I have edited my post and made the appropriate corrections to it,thanks for pointing out)
|Hmmm,noone has a clue?
Is this "MAOB inhibition + tryptamine" a completely virgin area of experimentation?
Since selegiline is quite popular amongst "smart drug enthusiasts" and tryptamines is something well....widespread at least amongst knowledgable people i wonder why there are no data on their combination.
At best im looking for a theory behind this combination,that is "what could happen based on neurochemistry/pharmacology that we know".A firsthand or a SWIM experience would also suffice
in short, yes it would. selegeline (l-dep) is a tricky bastard and an irreversible and non-selective MAO inhibitor at higher doses. given individual metabolic differences, this may well hold true for lower doses, especially w/coadministration of strong cerebral activators.
you are on the money about the dopaminergic effects which manifest as a dirty body load in the best of cases, adding a whole new level of distortion to the experience.
anecdotal ADRs (over 50 collected) from intentional and accidental coingestion of l-deprenyl with tryptamines / 2C-X-X family include severe and unpredictable crosspotentiation, peripheral vascular events, hypertension, tachycardia and severe and persistent circadian headaches.
as well as acute, nasty, full blown psychedelic freakouts.
if you are chasing that elusive pharmahuasca revelation, stand warned.
Swim has read several reports of adverse interactions between Selegiline and 2C-T-x's, but not tryptamines.
The following is not recommended; simply provided as a datapoint. At the time Swim had been taking Selegiline @ 15 mg daily for approximately 2 weeks and found it to be an effective pro-motivational antidepressant and nootropic.
Swim took 30 mg 4-HO-MiPT HCl orally. (This was a substance and a doseage level with which Swim was familiar, albeit not in combination with Selegiline. On a number of prior occasions, 30 mg 4-HO-MiPT had provided a gratifyingly involving "signature" tryptamine experience comparable for Swim to perhaps 5-7 grams dried psilocybe cubensis mushrooms. 4-HO-MiPT is Swim's favorite tryptamine, extremely vibrant and positive.)
In combination with the Selegiline, the 4-HO-MiPT was quite a bit stronger than it had been in previous excursions. The intensity of the experience significantly exceeded that described in the 20 mg report in TiHKAL, and could only be described as revelatory.
For approximately 90 minutes, Swim had what could be described as massive ecstatic out-of-body ego dissolution. In contrast to Swim's previous psychedelic experiences, Swim was disinclined to move or communicate with others at all, though it was possible with great mental effort. Throughout the experience, Swim had a carcinoid flush and noticeable pressor symptoms. These physical effects were not present without Selegiline, and were unpleasant.
Despite the vast and unexpected strength of the mental effects, and the appearance of unwanted physical side effects, for Swim the experience was extremely positive overall.
With a different set /or setting, or a different individual, the results could have easily been doubleplus ungood.
A last note; the length of the 4-HO-MiPT experience was substantially unchanged by Selegiline; that is to say the plateau lasted about 4 hours with a 2-4 hour afterglow.
boot from the shadow of a broken mirror
Very Nice information guys!
Yes,with phenethylamines bad reactions can be explainable...
So as i see there was some interaction between the tryptamine and selegiline! What i can comment on was that you were on a high dose regimen of selegiline,so you could possibly have had full MAOB inhibition.
Maybe the experience profile would differ if it was a one time administration or if harmine/harmaline was addes as in an ayahuasca!
Thank you very much for the information if someone has mor feedback i would appreciate it!