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All 3 posts Subject: NOS inhibition and ephedrine Please login to post Down

longimanus
(Hive Bee)
10-31-04 09:57
No 538897
User Picture       NOS inhibition and ephedrine

Effect of inhibition of nitric oxide synthase on the vasopressor response to ephedrine
Paul A Dabisch, John T Liles, Philip J Kadowitz
Canadian Journal of Physiology and Pharmacology. Ottawa: Oct 2003. Vol. 81, Iss. 10; p. 966

Abstract:
Ephedrine is a mixed adrenergic agonist, stimulating both alpha- and beta-adrenergic receptors. The effects of ephedrine use include increases in heart rate, cardiac output, peripheral resistance, and blood pressure, and its use is associated with serious cardiovascular events such as stroke, arrhythmias, and myocardial infarction. The vascular endothelium plays a fundamental role in the regulation of vascular tone by releasing vasoactive factors such as nitric oxide (NO). The loss of NO bioactivity, often referred to as endothelial dysfunction, is characterized by the loss of endothelium-dependent vasodilation and is thought to be a common pathway for cardiovascular events such as vasospasm, hypertension, and myocardial infarction. Since endothelial dysfunction is characterized by loss of NO activity, and since ephedrine and endothelial dysfunction may be associated with similar cardiovascular events, the current study was undertaken to determine the effect of inhibition of NO production on responses to ephedrine in the rat. A sodium nitroprusside (SNP) infusion procedure was used to restore baseline vascular parameters to pre-L-NAME levels, allowing for direct comparison of agonist responses before and after NOS inhibition. The results demonstrate that the vascular response to ephedrine in the rat is modulated by NO and that NO production in response to ephedrine may be secondary to beta 2-receptor stimulation.

Lilienthal
(Moderator)
10-31-04 13:45
No 538910
User Picture       Is there a particular reason that you clog the

Is there a particular reason that you clog the precious harddisk space of our server with this file? Why should anybody be interested in this topic and why did you have to upload the article instead of just posting the doi an/or a medline number?

longimanus
(Hive Bee)
10-31-04 16:00
No 538918
User Picture       Reasons

What about a possible new way for controling the side effects of stimulants? Modifying the experience? Also, I haven`t seen many articles in the Hive on the pharmacological action of this mediator.Viagra wink ? I hope this is somehow enough.

But, nevermind, when I was uploading this I really hesitated about doing it. I`ve had problems with low disk space too frown so I understand you. And I have a suggestion. I`ll upload the PDF in my homepage, post the link and you will delete the PDF in the Hive. This way we`ll save ~2,5MB precious space (no irony).

NOS inhibition and ephedrine (http://sinkology.tripod.com/PDF/Ephedrine.pdf)

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	All 3 posts		Subject: NOS inhibition and ephedrine		Please login to post		Down


		longimanus (Hive Bee) 10-31-04 09:57 No 538897				NOS inhibition and ephedrine
						Effect of inhibition of nitric oxide synthase on the vasopressor response to ephedrine Paul A Dabisch, John T Liles, Philip J Kadowitz Canadian Journal of Physiology and Pharmacology. Ottawa: Oct 2003. Vol. 81, Iss. 10; p. 966 Abstract: Ephedrine is a mixed adrenergic agonist, stimulating both alpha- and beta-adrenergic receptors. The effects of ephedrine use include increases in heart rate, cardiac output, peripheral resistance, and blood pressure, and its use is associated with serious cardiovascular events such as stroke, arrhythmias, and myocardial infarction. The vascular endothelium plays a fundamental role in the regulation of vascular tone by releasing vasoactive factors such as nitric oxide (NO). The loss of NO bioactivity, often referred to as endothelial dysfunction, is characterized by the loss of endothelium-dependent vasodilation and is thought to be a common pathway for cardiovascular events such as vasospasm, hypertension, and myocardial infarction. Since endothelial dysfunction is characterized by loss of NO activity, and since ephedrine and endothelial dysfunction may be associated with similar cardiovascular events, the current study was undertaken to determine the effect of inhibition of NO production on responses to ephedrine in the rat. A sodium nitroprusside (SNP) infusion procedure was used to restore baseline vascular parameters to pre-L-NAME levels, allowing for direct comparison of agonist responses before and after NOS inhibition. The results demonstrate that the vascular response to ephedrine in the rat is modulated by NO and that NO production in response to ephedrine may be secondary to beta 2-receptor stimulation.



		Lilienthal (Moderator) 10-31-04 13:45 No 538910				Is there a particular reason that you clog the
						Is there a particular reason that you clog the precious harddisk space of our server with this file? Why should anybody be interested in this topic and why did you have to upload the article instead of just posting the doi an/or a medline number?



		longimanus (Hive Bee) 10-31-04 16:00 No 538918				Reasons
						What about a possible new way for controling the side effects of stimulants? Modifying the experience? Also, I haven`t seen many articles in the Hive on the pharmacological action of this mediator.Viagra? I hope this is somehow enough. But, nevermind, when I was uploading this I really hesitated about doing it. I`ve had problems with low disk space too so I understand you. And I have a suggestion. I`ll upload the PDF in my homepage, post the link and you will delete the PDF in the Hive. This way we`ll save ~2,5MB precious space (no irony). NOS inhibition and ephedrine (http://sinkology.tripod.com/PDF/Ephedrine.pdf)

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