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|Subject: NOS inhibition and ephedrine
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|NOS inhibition and ephedrine
Effect of inhibition of nitric oxide synthase on the vasopressor response to ephedrine
Paul A Dabisch, John T Liles, Philip J Kadowitz
Canadian Journal of Physiology and Pharmacology. Ottawa: Oct 2003. Vol. 81, Iss. 10; p. 966
Ephedrine is a mixed adrenergic agonist, stimulating both alpha- and beta-adrenergic receptors. The effects of ephedrine use include increases in heart rate, cardiac output, peripheral resistance, and blood pressure, and its use is associated with serious cardiovascular events such as stroke, arrhythmias, and myocardial infarction. The vascular endothelium plays a fundamental role in the regulation of vascular tone by releasing vasoactive factors such as nitric oxide (NO). The loss of NO bioactivity, often referred to as endothelial dysfunction, is characterized by the loss of endothelium-dependent vasodilation and is thought to be a common pathway for cardiovascular events such as vasospasm, hypertension, and myocardial infarction. Since endothelial dysfunction is characterized by loss of NO activity, and since ephedrine and endothelial dysfunction may be associated with similar cardiovascular events, the current study was undertaken to determine the effect of inhibition of NO production on responses to ephedrine in the rat. A sodium nitroprusside (SNP) infusion procedure was used to restore baseline vascular parameters to pre-L-NAME levels, allowing for direct comparison of agonist responses before and after NOS inhibition. The results demonstrate that the vascular response to ephedrine in the rat is modulated by NO and that NO production in response to ephedrine may be secondary to beta 2-receptor stimulation.
|Is there a particular reason that you clog the
Is there a particular reason that you clog the precious harddisk space of our server with this file? Why should anybody be interested in this topic and why did you have to upload the article instead of just posting the doi an/or a medline number?
What about a possible new way for controling the side effects of stimulants? Modifying the experience? Also, I haven`t seen many articles in the Hive on the pharmacological action of this mediator.Viagra? I hope this is somehow enough.
But, nevermind, when I was uploading this I really hesitated about doing it. I`ve had problems with low disk space too so I understand you. And I have a suggestion. I`ll upload the PDF in my homepage, post the link and you will delete the PDF in the Hive. This way we`ll save ~2,5MB precious space (no irony).
NOS inhibition and ephedrine (http://sinkology.tripod.com/PDF/Ephedrine.pdf)