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All 7 posts Subject: Xylene vs DCM for MDP2P Please login to post Down

DiMethyl
(Hive Bee)
11-05-04 23:15
No 539922
      Xylene vs DCM for MDP2P

One was wondering if xylene could be used in place of DCM for extracting MDP2P from the Benzoquinone Wacker Oxidation of Safrole in Methanol mixture?
Anyone here ever read anything about that?
DiMethyl

If Something can go wrong----it will!!

ApprenticeCook
(Hive Addict)
11-06-04 04:38
No 539982
      NP solvent requried....

NP solvent requried....

DCM is easier to see from post wacker mix so you can sperate it but any NP will do just as well, make sure you add plenty of NP and agitate, and do several extractions, pool and evap solvent.

-AC

Its just my opinion, but no-one listens to me anyway, and rightly so...

DiMethyl
(Hive Bee)
11-07-04 05:50
No 540132
      Xylene vs DCM for MDP2P

Well---there are degrees of polarity and degrees of solubility, so things are never as simple as they may appear on the surface.

DiMethyl

If Something can go wrong----it will!!

ApprenticeCook
(Hive Addict)
11-07-04 10:14
No 540171
      thats why i said if you dont use DCM make sure

thats why i said if you dont use DCM make sure you do several more extraction washes than normal, this will be sure to counteract any solubility differnces....

Why did you ask the question if you already knew the answer?

-AC

Its just my opinion, but no-one listens to me anyway, and rightly so...

DiMethyl
(Hive Bee)
11-07-04 20:50
No 540238
      Xylene vs DCM for MDP2P

I asked the question because I have never seen posted anywhere anything about the solubility of mdp2p in xylene, and I have looked extensively.
Considering the relative chemistries of the respective molecules, it would seem reasonable that xylene would dissolve the ketone.
But then chemistry is complex and I was looking for perhaps some input from someone with some actual experience with this issue.
DiMethyl

If Something can go wrong----it will!!

indole_amine
(Hive Bee)
11-08-04 00:34
No 540279
User Picture       DCM vs. Xylene

DCM is better - it rips the crap out of every aequous solution. But Xylene is a powerful nonpolar, too - just not as miscible with water as DCM, therefore you have to do several extractions (3-5x) with more Xylene (like 3x100ml for extracting 500ml aequous soln.) and probably you'll have to fight emulsions; in contrast to DCM, where 3x65ml would probably suffice to give the same result, with easy separation (I LOVE bottom pullers! smile ).

_{indole_amine}

ApprenticeCook
(Hive Addict)
11-08-04 12:23
No 540406
      I was looking for perhaps some input from...

I was looking for perhaps some input from someone with some actual experience with this issue
And what is that supposed to mean?
man i told you the answer, DCM is better but xylene will still do the job, but you have to do more extractions, as indole has confirmed what i have said...

I cant speak for indole but as for me that IS coming from someone with exp in the field...

So, just for clarity....
I have so far said:
add plenty of NP and agitate, and do several extractions, pool and evap solvent
and then again:
make sure you do several more extraction washes than normal, this will be sure to counteract any solubility differnces....

Do you need it said AGAIN?

Well here it is....
DCM is better than Xylene (in this case), solubility ratio yes will be different but the main point of DCM's use is to allow easier seperation as (once again) indole has confirmed... if you cant find DCM (and god only knows why not) xylene will do but use more volume of NP and do several more washes and make sure to agitate plenty and let it settle before seperation.

-AC

Its just my opinion, but no-one listens to me anyway, and rightly so...

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	All 7 posts		Subject: Xylene vs DCM for MDP2P		Please login to post		Down


		DiMethyl (Hive Bee) 11-05-04 23:15 No 539922				Xylene vs DCM for MDP2P
						One was wondering if xylene could be used in place of DCM for extracting MDP2P from the Benzoquinone Wacker Oxidation of Safrole in Methanol mixture? Anyone here ever read anything about that? DiMethyl If Something can go wrong----it will!!



		ApprenticeCook (Hive Addict) 11-06-04 04:38 No 539982				NP solvent requried....
						NP solvent requried.... DCM is easier to see from post wacker mix so you can sperate it but any NP will do just as well, make sure you add plenty of NP and agitate, and do several extractions, pool and evap solvent. -AC Its just my opinion, but no-one listens to me anyway, and rightly so...



		DiMethyl (Hive Bee) 11-07-04 05:50 No 540132				Xylene vs DCM for MDP2P
						Well---there are degrees of polarity and degrees of solubility, so things are never as simple as they may appear on the surface. DiMethyl If Something can go wrong----it will!!



		ApprenticeCook (Hive Addict) 11-07-04 10:14 No 540171				thats why i said if you dont use DCM make sure
						thats why i said if you dont use DCM make sure you do several more extraction washes than normal, this will be sure to counteract any solubility differnces.... Why did you ask the question if you already knew the answer? -AC Its just my opinion, but no-one listens to me anyway, and rightly so...



		DiMethyl (Hive Bee) 11-07-04 20:50 No 540238				Xylene vs DCM for MDP2P
						I asked the question because I have never seen posted anywhere anything about the solubility of mdp2p in xylene, and I have looked extensively. Considering the relative chemistries of the respective molecules, it would seem reasonable that xylene would dissolve the ketone. But then chemistry is complex and I was looking for perhaps some input from someone with some actual experience with this issue. DiMethyl If Something can go wrong----it will!!



		indole_amine (Hive Bee) 11-08-04 00:34 No 540279				DCM vs. Xylene
						DCM is better - it rips the crap out of every aequous solution. But Xylene is a powerful nonpolar, too - just not as miscible with water as DCM, therefore you have to do several extractions (3-5x) with more Xylene (like 3x100ml for extracting 500ml aequous soln.) and probably you'll have to fight emulsions; in contrast to DCM, where 3x65ml would probably suffice to give the same result, with easy separation (I LOVE bottom pullers! ). _{indole_amine}



		ApprenticeCook (Hive Addict) 11-08-04 12:23 No 540406				I was looking for perhaps some input from...
						I was looking for perhaps some input from someone with some actual experience with this issue And what is that supposed to mean? man i told you the answer, DCM is better but xylene will still do the job, but you have to do more extractions, as indole has confirmed what i have said... I cant speak for indole but as for me that IS coming from someone with exp in the field... So, just for clarity.... I have so far said: add plenty of NP and agitate, and do several extractions, pool and evap solvent and then again: make sure you do several more extraction washes than normal, this will be sure to counteract any solubility differnces.... Do you need it said AGAIN? Well here it is.... DCM is better than Xylene (in this case), solubility ratio yes will be different but the main point of DCM's use is to allow easier seperation as (once again) indole has confirmed... if you cant find DCM (and god only knows why not) xylene will do but use more volume of NP and do several more washes and make sure to agitate plenty and let it settle before seperation. -AC Its just my opinion, but no-one listens to me anyway, and rightly so...

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