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General Discourse | |
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All posts | Subject: New m-Opioid Receptor Agonists . | Please login to post | |
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KLt (Newbee) 11-09-04 06:36 No 540593 |
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New m-Opioid Receptor Agonists . (Rated as: good read) |
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Chem. Pharm. Bull. 49(10) 1314—1320 (2001) Vol. 49, No. 10 New m-Opioid Receptor Agonists with Piperazine Moiety Teruo KOMOTO,*,a,c Tomomi OKADA,a Susumu SATO,a Yasuhiro NIINO,b Tetsuo OKA,b and Takao SAKAMOTO*,c Abstract New m-opioid receptor (MOR) agonists containing piperazine and homopiperazine moieties in the structures were synthesized and their affinities to and agonist potencies on MOR were evaluated. Among the synthesized compounds, 4-[4-(2-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide (20Aa) showed the highest affinity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells, and the highest agonist potency on the MOR in isolated guinea-pig ileum preparation. Edit:references added |
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