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All 4 posts Subject: Rat mg/kg dosages differ from humans, obviously... Please login to post Down

BlaseDeviant
(Hive Bee)
11-05-04 23:55
No 539929
      Rat mg/kg dosages differ from humans, obviously...

...but I remember seeing a number by which you divided the rat mg/kg dose to come up with an equivalent human dose.

Is there such a number, or would it differ greatly by drug, and the one I saw was either BS or a figment of my imagination?

So differently divine...

ApprenticeCook
(Hive Addict)
11-06-04 04:20
No 539976
      you can usually get LD numbers in mg of drug...

you can usually get LD numbers in mg of drug per g of rat or mouse, you could multiply this out to get human dose by weight of ther person..

But i would highly not recommend doing so as this is very unreliable depending on the substance.

-AC

Its just my opinion, but no-one listens to me anyway, and rightly so...

indole
(Hive Bee)
11-12-04 04:57
No 541159
      At least for Meth/amph the rat dosage is ~10x...

At least for Meth/amph the rat dosage is ~10x that of humans... it is metabolized much, much faster...

amines to an end

Fastandbulbous
(Hive Bee)
11-12-04 23:57
No 541300
User Picture       Very unreliable

With rats, you can feed them bucketloads of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and they don't develop Parkinson's like symptoms, and their substantia nigra is untouched. On the other hand, give a primate a one off dose, and they all end up with severe Parkinson's and an extremely damaged substantia nigra, just like the people who got some MPPP from a fucked up synth in California.

Sometimes we have metabolic routes so different from non-primates that the dosage figures are meaningless

That is right, the Mascara Snake: Fast and bulbous

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	All 4 posts		Subject: Rat mg/kg dosages differ from humans, obviously...		Please login to post		Down


		BlaseDeviant (Hive Bee) 11-05-04 23:55 No 539929				Rat mg/kg dosages differ from humans, obviously...
						...but I remember seeing a number by which you divided the rat mg/kg dose to come up with an equivalent human dose. Is there such a number, or would it differ greatly by drug, and the one I saw was either BS or a figment of my imagination? So differently divine...



		ApprenticeCook (Hive Addict) 11-06-04 04:20 No 539976				you can usually get LD numbers in mg of drug...
						you can usually get LD numbers in mg of drug per g of rat or mouse, you could multiply this out to get human dose by weight of ther person.. But i would highly not recommend doing so as this is very unreliable depending on the substance. -AC Its just my opinion, but no-one listens to me anyway, and rightly so...



		indole (Hive Bee) 11-12-04 04:57 No 541159				At least for Meth/amph the rat dosage is ~10x...
						At least for Meth/amph the rat dosage is ~10x that of humans... it is metabolized much, much faster... amines to an end



		Fastandbulbous (Hive Bee) 11-12-04 23:57 No 541300				Very unreliable
						With rats, you can feed them bucketloads of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and they don't develop Parkinson's like symptoms, and their substantia nigra is untouched. On the other hand, give a primate a one off dose, and they all end up with severe Parkinson's and an extremely damaged substantia nigra, just like the people who got some MPPP from a fucked up synth in California. Sometimes we have metabolic routes so different from non-primates that the dosage figures are meaningless That is right, the Mascara Snake: Fast and bulbous

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